{"product_id":"cagrilintide-glp-1-blend","title":"Cagrilintide + GLP-1 Blend","description":"\u003cp\u003eCagrilintide + GLP-1 Blend — a metabolic research material, supplied as a vial with third-party analytical testing and per-batch documentation.\u003c\/p\u003e\u003ch3\u003eAbout Cagrilintide + GLP-1 Blend\u003c\/h3\u003e\u003cp\u003eThis research blend combines two distinct metabolic peptides in a single vial: cagrilintide, a synthetic long-acting amylin analog that agonizes amylin (AMY1-3) and calcitonin receptors, and GLP-1, the native incretin peptide that agonizes the glucagon-like peptide-1 receptor (GLP-1R). Because it is a physical mixture of two molecules, the blend has no single molecular formula, weight, or CAS number; each component retains its own identity, and the relevant specifications are listed per component below.\u003c\/p\u003e\u003cp\u003eIn preclinical research, the pairing of an amylin analog with a GLP-1 receptor agonist has been of interest for studying complementary signaling across the amylin and incretin axes in models of energy balance, food intake, and glucose handling. This co-formulation mirrors the scientific rationale behind combination amylin\/GLP-1 research programs. This material is supplied strictly for Research Use Only and is not for human or animal use.\u003c\/p\u003e\u003ch3\u003eSpecifications\u003c\/h3\u003e\u003ch4\u003eIdentification\u003c\/h4\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMaterial:\u003c\/strong\u003e Cagrilintide + GLP-1 Blend\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAlso searched as:\u003c\/strong\u003e AM833\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eResearch Area:\u003c\/strong\u003e Metabolic Research\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePresentation:\u003c\/strong\u003e Vial\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAvailable Sizes:\u003c\/strong\u003e 2.5mg\/2.5mg (5mg) · 5mg\/5mg (10mg)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eType:\u003c\/strong\u003e Two-component peptide blend (amylin analog + incretin)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReceptor \/ Target:\u003c\/strong\u003e Amylin \/ calcitonin receptors (cagrilintide) and GLP-1R (GLP-1)\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch4\u003eAnalytical Data\u003c\/h4\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity (HPLC):\u003c\/strong\u003e ≥99%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIdentity (MS):\u003c\/strong\u003e Confirmed to specification\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTesting:\u003c\/strong\u003e Accredited (ISO 17025) third-party laboratory\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDocumentation:\u003c\/strong\u003e Per-batch COA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch4\u003eComponent Profiles\u003c\/h4\u003e\u003ch4\u003eCagrilintide\u003c\/h4\u003e\u003cul\u003e\n\u003cli\u003eFormula \u003cb\u003eC194H312N54O59S2\u003c\/b\u003e\n\u003c\/li\u003e\n\u003cli\u003eWeight \u003cb\u003e4409.1 g\/mol\u003c\/b\u003e\n\u003c\/li\u003e\n\u003cli\u003eCAS \u003cb\u003e1415456-99-3\u003c\/b\u003e\n\u003c\/li\u003e\n\u003cli\u003eStructure \u003cb\u003eSynthetic 37-residue acylated cyclic peptide; (Eicosanedioic acid-γ-Glu)-KCNTATCATQRLAEFLRHSSNNFGPILPPTNVGSNTP-NH2 with Cys2-Cys7 disulfide\u003c\/b\u003e\n\u003c\/li\u003e\n\u003cli\u003eReceptor \u003cb\u003eAmylin receptors (AMY1-3) and calcitonin receptor (CTR)\u003c\/b\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch4\u003eGLP-1 (7-37)\u003c\/h4\u003e\u003cul\u003e\n\u003cli\u003eFormula \u003cb\u003eC151H228N40O47\u003c\/b\u003e\n\u003c\/li\u003e\n\u003cli\u003eWeight \u003cb\u003e3355.71 g\/mol\u003c\/b\u003e\n\u003c\/li\u003e\n\u003cli\u003eCAS \u003cb\u003e106612-94-6\u003c\/b\u003e\n\u003c\/li\u003e\n\u003cli\u003eStructure \u003cb\u003eNative linear 30-residue incretin peptide; HAEGTFTSDVSSYLEGQAAKEFIAWLVKGR\u003c\/b\u003e\n\u003c\/li\u003e\n\u003cli\u003eReceptor \u003cb\u003eGlucagon-like peptide-1 receptor (GLP-1R)\u003c\/b\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch4\u003eKey Characteristics\u003c\/h4\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Type:\u003c\/strong\u003e Two-component peptide blend\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReceptor \/ Target:\u003c\/strong\u003e Amylin\/calcitonin receptors and GLP-1R\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Co-lyophilized powder in vial\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e Store lyophilized at -20 C to -80 C; protect from light\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStability:\u003c\/strong\u003e Lyophilized stable for extended periods frozen\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch4\u003eResearch Context\u003c\/h4\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eAmylin \/ incretin co-signaling —\u003c\/strong\u003e Model system for complementary activation of amylin and GLP-1 receptor axes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEnergy balance research —\u003c\/strong\u003e Used in preclinical study of food intake and body-weight regulation.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGlucose homeostasis —\u003c\/strong\u003e Combined agonism studied in cell-based and animal glucose-handling models.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCombination formulation studies —\u003c\/strong\u003e Reflects the research rationale of amylin\/GLP-1 combination approaches.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch4\u003eResearch Findings\u003c\/h4\u003e\u003cp\u003ePreclinical research on combined amylin-analog and GLP-1 receptor agonist research has explored whether the two mechanisms produce complementary effects on satiety, food intake, and metabolic parameters relative to either agent alone. Findings are specific to the experimental models used and to the individual pharmacology of each component.\u003c\/p\u003e\u003cp\u003eThese observations derive from experimental and preclinical settings and are provided for scientific context only. No human efficacy or therapeutic conclusions are implied by this listing.\u003c\/p\u003e\u003ch4\u003eHistory\u003c\/h4\u003e\u003cp\u003eThe scientific rationale for pairing an amylin analog with a GLP-1 agonist grew out of parallel development of long-acting amylin analogs such as cagrilintide and the established GLP-1 incretin field, exemplified by combination programs studying amylin plus GLP-1 receptor agonism for metabolic research.\u003c\/p\u003e\u003ch4\u003eReferences\u003c\/h4\u003e\u003col\u003e\n\u003cli\u003eKruse T, et al. (2021). Development of Cagrilintide, a Long-Acting Amylin Analogue. Journal of Medicinal Chemistry.\u003c\/li\u003e\n\n\u003cli\u003eMojsov S, Weir GC, Habener JF (1987). Insulinotropin: glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas. Journal of Clinical Investigation.\u003c\/li\u003e\n\u003c\/ol\u003e\u003cp\u003eCited literature refers to laboratory and preclinical research. Cagrilintide + GLP-1 Blend is supplied strictly for research use only and is not intended to diagnose, treat, cure, or prevent any disease.\u003c\/p\u003e\u003ch4\u003eWhy researchers choose Helio\u003c\/h4\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003e99%+ Purity —\u003c\/strong\u003e HPLC-verified every batch\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAccredited Testing —\u003c\/strong\u003e Independent ISO 17025 laboratory\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePer-Batch COA —\u003c\/strong\u003e Documentation tied to your lot\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMade in the USA —\u003c\/strong\u003e Discreet, protected shipping\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch4\u003eFrequently Asked\u003c\/h4\u003e\u003cp\u003e\u003cstrong\u003eAre these research materials third-party tested?\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eYes — every batch is analysed by an accredited (ISO 17025) independent laboratory using HPLC and mass spectrometry, with a per-batch Certificate of Analysis.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eWhat purity are the materials?\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eMaterials are verified to 99%+ HPLC purity. Any batch that does not meet the threshold is not released.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eDo you provide a Certificate of Analysis (COA)?\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eYes. Per-batch COA documentation is provided and is traceable by lot number.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eWhere do you ship from?\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eMaterials are shipped from the USA in discreet, protective packaging.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eAre these products for human use?\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eNo. All materials are sold strictly for laboratory research use only — not for human or animal consumption, diagnosis, treatment, or prevention of any disease.\u003c\/p\u003e\u003cp\u003e\u003cem\u003eResearch use only — not for human or animal consumption. Per-batch documentation is provided with the material.\u003c\/em\u003e\u003c\/p\u003e","brand":"heliopeptides","offers":[{"title":"2.5mg\/2.5mg (5mg)","offer_id":67669937815795,"sku":null,"price":58.47,"currency_code":"USD","in_stock":true},{"title":"5mg\/5mg (10mg)","offer_id":67669937848563,"sku":null,"price":110.47,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0825\/8791\/0387\/files\/7e8cdeb2df60.webp?v=1791395026","url":"https:\/\/heliopeptides.com\/products\/cagrilintide-glp-1-blend","provider":"Helio Peptides","version":"1.0","type":"link"}