{"product_id":"cagrilintide","title":"Cagrilintide","description":"\u003cp\u003eCagrilintide — a metabolic research material, supplied as a vial with third-party analytical testing and per-batch documentation.\u003c\/p\u003e\u003ch3\u003eAbout Cagrilintide\u003c\/h3\u003e\u003cp\u003eCagrilintide (development code AM833) is a synthetic, long-acting amylin analog built on a 37-amino-acid pramlintide-like backbone with key substitutions and N-terminal fatty-diacid acylation via a gamma-glutamic acid linker. It contains an intramolecular disulfide bridge (Cys2-Cys7) and a C-terminal amide. In experimental systems it acts as a non-selective agonist of the amylin receptor family (AMY1-3) and the calcitonin receptor, with reported subpicomolar to picomolar binding affinities.\u003c\/p\u003e\u003cp\u003eIn preclinical and in-vitro research, cagrilintide has been studied for its prolonged receptor engagement relative to native amylin, and as a combination partner with GLP-1 receptor agonists in models of energy balance and food intake. Its acylation-based design confers extended circulating half-life, making it a reference amylin-class research peptide. This material is supplied strictly for Research Use Only.\u003c\/p\u003e\u003ch3\u003eSpecifications\u003c\/h3\u003e\u003ch4\u003eIdentification\u003c\/h4\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMaterial:\u003c\/strong\u003e Cagrilintide\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAlso searched as:\u003c\/strong\u003e AM833\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eResearch Area:\u003c\/strong\u003e Metabolic Research\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePresentation:\u003c\/strong\u003e Vial\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAvailable Sizes:\u003c\/strong\u003e 5mg · 10mg\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 1415456-99-3\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e C194H312N54O59S2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 4409.1 g\/mol\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eType:\u003c\/strong\u003e Synthetic acylated cyclic peptide (amylin analog)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReceptor \/ Target:\u003c\/strong\u003e Amylin receptors (AMY) and calcitonin receptor (CTR)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePubChem CID:\u003c\/strong\u003e \u003ca href=\"https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/164618153\" target=\"_blank\" rel=\"noopener\"\u003e164618153\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch4\u003eAmino Acid Sequence\u003c\/h4\u003e\u003cp\u003e(Eicosanedioic acid-γ-Glu)-KCNTATCATQRLAEFLRHSSNNFGPILPPTNVGSNTP-NH2 (Cys2-Cys7 disulfide)\u003c\/p\u003e\u003ch4\u003eAnalytical Data\u003c\/h4\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity (HPLC):\u003c\/strong\u003e ≥99%\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIdentity (MS):\u003c\/strong\u003e Confirmed to specification\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTesting:\u003c\/strong\u003e Accredited (ISO 17025) third-party laboratory\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDocumentation:\u003c\/strong\u003e Per-batch COA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch4\u003eKey Characteristics\u003c\/h4\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e C194H312N54O59S2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 4409.1 g\/mol\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 1415456-99-3\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePubChem CID:\u003c\/strong\u003e 164618153\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReceptor \/ Target:\u003c\/strong\u003e Amylin receptors (AMY1-3) and calcitonin receptor (CTR)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Type:\u003c\/strong\u003e Synthetic 37-residue acylated cyclic peptide\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilized powder in vial\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e Store lyophilized at -20 C to -80 C; protect from light\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStability:\u003c\/strong\u003e Lyophilized stable for extended periods frozen\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch4\u003eResearch Context\u003c\/h4\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eAmylin receptor pharmacology —\u003c\/strong\u003e Reference agonist for AMY1-3 and calcitonin receptor binding and signaling studies.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEnergy balance and satiety research —\u003c\/strong\u003e Model peptide used in preclinical study of food intake and body-weight regulation.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGLP-1 co-agonism studies —\u003c\/strong\u003e Frequently paired with GLP-1R agonists in combination metabolic-research models.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLong-acting peptide design —\u003c\/strong\u003e Illustrates fatty-diacid acylation strategy for extended half-life amylin analogs.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch4\u003eResearch Findings\u003c\/h4\u003e\u003cp\u003ePreclinical and early clinical-pharmacology research characterizes cagrilintide as a long-acting amylin analog with potent activity at amylin and calcitonin receptors and a markedly extended duration of action compared with native amylin. Studies have examined its effects on food intake and body weight in animal models and its combination with GLP-1 receptor agonists.\u003c\/p\u003e\u003cp\u003eThese observations derive from experimental and preclinical settings and are provided for scientific context only. No human efficacy or therapeutic conclusions are implied by this listing.\u003c\/p\u003e\u003ch4\u003eHistory\u003c\/h4\u003e\u003cp\u003eCagrilintide (AM833) was developed by Novo Nordisk as a long-acting amylin analog, extending the amylin-pharmacology field established by the earlier analog pramlintide. Its discovery and early pharmacology were reported by Kruse and colleagues, and it has since been studied both alone and in fixed combination with the GLP-1 agonist a long-acting GLP-1 receptor agonist (a cagrilintide + GLP-1 agonist combination).\u003c\/p\u003e\u003ch4\u003eReferences\u003c\/h4\u003e\u003col\u003e\n\u003cli\u003eKruse T, et al. (2021). Development of Cagrilintide, a Long-Acting Amylin Analogue. Journal of Medicinal Chemistry.\u003c\/li\u003e\n\n\n\u003c\/ol\u003e\u003cp\u003e\u003ca href=\"https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/164618153\" target=\"_blank\" rel=\"noopener\"\u003eView compound profile on NIH PubChem\u003c\/a\u003e\u003c\/p\u003e\u003cp\u003eCited literature refers to laboratory and preclinical research. Cagrilintide is supplied strictly for research use only and is not intended to diagnose, treat, cure, or prevent any disease.\u003c\/p\u003e\u003ch4\u003eWhy researchers choose Helio\u003c\/h4\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003e99%+ Purity —\u003c\/strong\u003e HPLC-verified every batch\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAccredited Testing —\u003c\/strong\u003e Independent ISO 17025 laboratory\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePer-Batch COA —\u003c\/strong\u003e Documentation tied to your lot\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMade in the USA —\u003c\/strong\u003e Discreet, protected shipping\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch4\u003eFrequently Asked\u003c\/h4\u003e\u003cp\u003e\u003cstrong\u003eAre these research materials third-party tested?\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eYes — every batch is analysed by an accredited (ISO 17025) independent laboratory using HPLC and mass spectrometry, with a per-batch Certificate of Analysis.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eWhat purity are the materials?\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eMaterials are verified to 99%+ HPLC purity. Any batch that does not meet the threshold is not released.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eDo you provide a Certificate of Analysis (COA)?\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eYes. Per-batch COA documentation is provided and is traceable by lot number.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eWhere do you ship from?\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eMaterials are shipped from the USA in discreet, protective packaging.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eAre these products for human use?\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eNo. All materials are sold strictly for laboratory research use only — not for human or animal consumption, diagnosis, treatment, or prevention of any disease.\u003c\/p\u003e\u003cp\u003e\u003cem\u003eResearch use only — not for human or animal consumption. Per-batch documentation is provided with the material.\u003c\/em\u003e\u003c\/p\u003e","brand":"heliopeptides","offers":[{"title":"5mg","offer_id":67669937651955,"sku":null,"price":38.97,"currency_code":"USD","in_stock":true},{"title":"10mg","offer_id":67669937684723,"sku":null,"price":45.47,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0825\/8791\/0387\/files\/2550379e8571.webp?v=1791395022","url":"https:\/\/heliopeptides.com\/products\/cagrilintide","provider":"Helio Peptides","version":"1.0","type":"link"}