{"product_id":"igf-1-lr3-1mg-vial","title":"IGF-1 LR3 1MG Research Vial - Long-Acting IGF-1 Analogue | Third-Party Tested","description":"\u003ch2 dir=\"ltr\"\u003e\u003cspan\u003eIGF-1 LR3 Research That Actually Gets Used\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eThe insulin-like growth factor axis is one of the most studied signalling systems in cell biology. At its centre is IGF-1 - a 70-amino acid peptide that drives cell proliferation, protein synthesis, glucose uptake, and survival signalling across virtually every tissue type. The research tools used to probe this system need to be precisely what they claim.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eHelio Peptides operates differently.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eEvery vial of IGF-1 LR3 goes through \u003c\/span\u003e\u003cspan\u003eindependent third-party testing at an ISO 17025-accredited laboratory\u003c\/span\u003e\u003cspan\u003e before it ships - identity confirmed by HPLC, molecular weight verified by mass spectrometry, and assay content confirmed at the labelled 1MG. The Certificate of Analysis is available on request for every batch.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eIGF-1 LR3 (Long R3 IGF-1) is a synthetic 83-amino acid analogue of human IGF-1, engineered with two key modifications that dramatically extend its functional half-life and biological potency in research settings: an N-terminal 13-amino acid extension and a glutamic acid-to-arginine substitution at position 3. The result is a compound with \u003c\/span\u003e\u003cspan\u003eapproximately 2–3x greater potency than native IGF-1\u003c\/span\u003e\u003cspan\u003e and a plasma half-life extended from approximately 12–15 hours (for native IGF-1) to 20–30 hours in published in vitro and in vivo model systems. At $59.95 per vial - or $53.96 in a pack of ten - Helio Peptides provides one of the most rigorously documented and cost-accessible sources of research-grade IGF-1 LR3 available from a US-based, ISO-accredited tested supplier. Researchers building GH\/IGF axis programmes may also be working with our \u003c\/span\u003e\u003ca href=\"https:\/\/heliopeptides.com\/products\/sermorelin-5mg-vial\"\u003e\u003cspan\u003eSermorelin 5MG Vial\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e for upstream GHRH-mediated GH stimulation, or our \u003c\/span\u003e\u003ca href=\"https:\/\/heliopeptides.com\/products\/aod-9604-vial\"\u003e\u003cspan\u003eAOD-9604 Vial\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e for GH fragment lipolysis research alongside IGF-1 LR3's anabolic and proliferative signalling studies.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003ch2 dir=\"ltr\"\u003e\u003cspan\u003eWhat Makes This Vial Different\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eIGF-1 LR3 is available from multiple research peptide suppliers. The difference is documentation. Here's what sets the Helio Peptides 1MG vial apart:\u003c\/span\u003e\u003c\/p\u003e\n\u003cp style=\"box-sizing: border-box; margin-block: 0px 0.9rem; color: rgb(41, 46, 76); font-family: 'Kumbh Sans', sans-serif; font-size: 16px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: rgb(255, 255, 255); text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;\"\u003e\u003cb\u003e\u003cbr\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eThird-party tested at an ISO 17025-accredited lab.\u003c\/span\u003e\u003cspan\u003e  The laboratory conducting the testing has been independently verified for technical accuracy - not self-certified. Every Helio Peptides IGF-1 LR3 batch is tested at such a facility. Full batch data is available in our \u003c\/span\u003e\u003ca href=\"https:\/\/heliopeptides.com\/certificate-of-analysis\"\u003e\u003cspan\u003eCertificate of Analysis\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eUSA manufactured.\u003c\/span\u003e\u003cspan\u003e  Synthesised by solid-phase peptide synthesis (SPPS) in a controlled US-based facility. Not imported bulk material relabelled domestically - manufactured, tested, and dispatched from the United States.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003e83-amino acid sequence confirmed by mass spectrometry.\u003c\/span\u003e\u003cspan\u003e  The full 83-amino acid sequence - including the N-terminal extension and R3 substitution - is verified at every batch by MS. At 9,111.46 g\/mol, IGF-1 LR3 is one of the larger synthetic peptides in the Helio range. Sequence fidelity at this scale requires rigorous MS confirmation.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eLyophilised for stability.\u003c\/span\u003e\u003cspan\u003e  Supplied as lyophilised powder - substantially more stable than solution formats during shipping and storage. Cold-chain packaging included on every order.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003e1MG vial - practical for research.\u003c\/span\u003e\u003cspan\u003e  The 1MG format is the standard for IGF-1 LR3 in research settings - sufficient for extensive cell-based assays and in vivo dosing studies. $59.95 single vial. $53.96 per vial in a pack of ten.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003ch2 dir=\"ltr\"\u003e\u003cspan\u003eWhat Is IGF-1 LR3?\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eIGF-1 LR3 - formally known as Long R3 Insulin-like Growth Factor-1 or Long R3 IGF-1 - is a synthetic analogue of human Insulin-like Growth Factor 1 (IGF-1) engineered for enhanced stability and potency in research applications. It was developed in the 1990s as a research tool to overcome two limitations of native IGF-1: its rapid clearance from the circulation and its high affinity for IGF-binding proteins (IGFBPs), which compete with IGF-1 receptors for IGF-1 binding and limit its bioavailability at target tissues.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eIGF-1 LR3 incorporates two structural modifications relative to native IGF-1 (CAS 67763-96-6): \u003c\/span\u003e\u003cspan\u003e(1) an N-terminal 13-amino acid extension\u003c\/span\u003e\u003cspan\u003e that reduces affinity for IGFBPs approximately 1,000-fold compared to native IGF-1, and \u003c\/span\u003e\u003cspan\u003e(2) a glutamic acid-to-arginine substitution at position 3\u003c\/span\u003e\u003cspan\u003e (the 'R3' designation) that further decreases IGFBP binding while maintaining full IGF-1 receptor (IGF-1R) affinity. The combined effect is a compound that retains the full signalling potency of native IGF-1 at the IGF-1 receptor while being substantially resistant to IGFBP-mediated sequestration - resulting in greater bioavailability at target cells and an extended functional half-life of approximately 20–30 hours versus 12–15 hours for native IGF-1.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eThese properties make IGF-1 LR3 the preferred form of IGF-1 for the majority of cell culture and in vivo research applications - it produces more consistent dose-response relationships than native IGF-1 because its activity is not confounded by variable IGFBP concentrations in serum-containing culture media or in vivo biological fluids.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eIGF-1 LR3 is a direct downstream signalling compound within the GH\/IGF axis - the same axis studied upstream using our \u003c\/span\u003e\u003ca href=\"https:\/\/heliopeptides.com\/products\/sermorelin-5mg-vial\"\u003e\u003cspan\u003eSermorelin 5MG Vial\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e (GHRH-mediated pituitary GH stimulation) and our \u003c\/span\u003e\u003ca href=\"https:\/\/heliopeptides.com\/products\/cjc-1295-dac-vial\"\u003e\u003cspan\u003eCJC-1295 (with DAC) Vial\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e (extended half-life GHRH analogue). Combining upstream GH secretagogue research with downstream IGF-1 LR3 axis research allows systematic characterisation of the complete somatotropic signalling cascade - from hypothalamic GHRH release through pituitary GH secretion to peripheral IGF-1 receptor activation and downstream PI3K\/Akt\/mTOR signalling.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eIGF-1 LR3 is distinct from our \u003c\/span\u003e\u003ca href=\"https:\/\/heliopeptides.com\/products\/igf-1-des-vial\"\u003e\u003cspan\u003eIGF-1 DES Vial\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e - a truncated form of IGF-1 lacking the first three N-terminal amino acids, which shows preferential local tissue activity due to its very low IGFBP affinity and very short half-life. Comparative studies between IGF-1 LR3 (systemic, extended half-life) and IGF-1 DES (local, short half-life) are a well-established design in IGF-1 receptor pharmacology research.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp style=\"box-sizing: border-box; margin-block: 0px 0.9rem; color: rgb(41, 46, 76); font-family: 'Kumbh Sans', sans-serif; font-size: 16px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: rgb(255, 255, 255); text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;\"\u003e\u003cb\u003e\u003cbr\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cdiv dir=\"ltr\" align=\"left\"\u003e\n\u003ctable\u003e\n\u003ccolgroup\u003e\u003ccol width=\"624\"\u003e\u003c\/colgroup\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003e\"IGF-1 LR3 is the gold standard for IGF-1 receptor research in cell culture. Its reduced IGFBP affinity eliminates one of the most significant confounding variables in serum-based cell culture experiments - you're dosing the receptor, not dosing the binding proteins. For any study requiring reproducible IGF-1R activation, LR3 is the form to use.\"\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003e- Growth factor research community on why IGF-1 LR3 outperforms native IGF-1 in cell culture\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003cp dir=\"ltr\"\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003ch2 dir=\"ltr\"\u003e\u003cspan\u003eResearch Applications\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eIGF-1 LR3 is one of the most broadly applied research peptides in cell biology, with documented research applications across virtually every tissue type that expresses the IGF-1 receptor. All applications described below are for controlled laboratory environments only. This product is for research use only and is not for human or animal consumption.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3 dir=\"ltr\"\u003e\u003cspan\u003eIGF-1 Receptor Signalling and PI3K\/Akt\/mTOR Pathway Research\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eThe primary research application for IGF-1 LR3 is systematic characterisation of \u003c\/span\u003e\u003cspan\u003eIGF-1 receptor (IGF-1R) signalling and the downstream PI3K\/Akt\/mTOR pathway\u003c\/span\u003e\u003cspan\u003e - one of the central survival, proliferation, and anabolic signalling axes in mammalian cell biology. IGF-1R is a receptor tyrosine kinase - upon IGF-1 LR3 binding, it autophosphorylates and recruits IRS-1 (Insulin Receptor Substrate-1), triggering PI3K activation, Akt phosphorylation (Thr308 and Ser473), and downstream mTORC1 activation (p70S6K, 4E-BP1). This signalling cascade drives protein synthesis, cell proliferation, inhibition of apoptosis, and glucose uptake through GLUT translocation.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eIGF-1 LR3's reduced IGFBP affinity makes it the preferred ligand for dose-response studies in serum-containing cell culture media - where native IGF-1 activity is significantly attenuated by endogenous IGFBPs present in serum. At concentrations from 1–100 ng\/mL, IGF-1 LR3 reliably activates IGF-1R in standard cell culture conditions, producing well-defined and reproducible phosphorylation cascades that are not observed with equivalent concentrations of native IGF-1 in the same serum-containing conditions.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3 dir=\"ltr\"\u003e\u003cspan\u003eSkeletal Muscle Biology and Hypertrophy Research\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eIGF-1 LR3 is one of the most widely used tools in \u003c\/span\u003e\u003cspan\u003eskeletal muscle cell biology research\u003c\/span\u003e\u003cspan\u003e. In primary myoblast and myotube cultures (C2C12 cells, primary human satellite cells), IGF-1 LR3 activates IGF-1R\/Akt\/mTOR signalling to drive myotube hypertrophy, protein synthesis (measured by puromycin incorporation or leucine labelling), and myogenic differentiation. These responses are significantly more robust and reproducible with IGF-1 LR3 than with native IGF-1 in serum-containing media.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eIn vivo murine studies examining skeletal muscle hypertrophy, fibre-type distribution, and regeneration after injury have used IGF-1 LR3 as both a positive control for IGF-1R-mediated anabolic signalling and as an interventional compound to examine the contribution of IGF-1 axis activity to muscle regeneration endpoints. Researchers examining exercise adaptation biology alongside IGF-1 LR3's anabolic signalling may also be working with our \u003c\/span\u003e\u003ca href=\"https:\/\/heliopeptides.com\/products\/mots-c-10mg-vial\"\u003e\u003cspan\u003eMOTS-c 10MG Vial\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e for AMPK-mediated exercise mimetic research, or our \u003c\/span\u003e\u003ca href=\"https:\/\/heliopeptides.com\/products\/slu-pp-332-5mg-vial\"\u003e\u003cspan\u003eSLU-PP-332 5MG Vial\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e for ERR-mediated mitochondrial biogenesis alongside IGF-1R anabolic pathway studies.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3 dir=\"ltr\"\u003e\u003cspan\u003eCell Proliferation and Survival Signalling Research\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eIGF-1 LR3 is extensively used as a \u003c\/span\u003e\u003cspan\u003epositive control and interventional compound in cell proliferation and anti-apoptotic signalling research\u003c\/span\u003e\u003cspan\u003e across a wide range of cell line models including fibroblasts, epithelial cells, endothelial cells, neuronal cells, hepatocytes, and cancer cell lines. Its reliable IGF-1R activation and well-characterised downstream signalling make it the standard reagent for studies examining: PI3K\/Akt\/mTOR pathway activation and inhibition (often used as a positive control alongside mTOR inhibitors such as rapamycin); IGF-1R-mediated inhibition of apoptosis through Akt-mediated Bad phosphorylation and Bcl-2 family regulation; IGF-1R cross-talk with EGFR, insulin receptor, and other RTK systems; and characterisation of IGF-1R expression levels and downstream signalling competence in primary cell isolates.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3 dir=\"ltr\"\u003e\u003cspan\u003eCancer Biology and IGF Axis Research\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eThe IGF-1 axis is one of the most studied signalling systems in cancer biology - IGF-1R overexpression and constitutive IGF-1R signalling are documented in a broad range of tumour types. IGF-1 LR3 is used in cancer research settings to characterise IGF-1R-dependent proliferation and survival signalling in cancer cell lines, to establish dose-response relationships for IGF-1R-targeted inhibitors, and to model the tumour microenvironment's contribution to IGF-1 axis activity in co-culture systems.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eResearch examining the IGF-1 axis in the context of treatment resistance - where IGF-1R signalling has been documented as a resistance mechanism to targeted therapies including anti-HER2 agents, EGFR inhibitors, and anti-oestrogen therapies - uses IGF-1 LR3 as the ligand of choice for its reproducible and IGFBP-independent IGF-1R activation. Researchers working in cancer biology may also be examining our \u003c\/span\u003e\u003ca href=\"https:\/\/heliopeptides.com\/products\/thymosin-alpha-1-5mg-vial\"\u003e\u003cspan\u003eThymosin Alpha 1 5MG Vial\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e for immunological mechanisms in tumour models, or our \u003c\/span\u003e\u003ca href=\"https:\/\/heliopeptides.com\/products\/bpc-157-vial\"\u003e\u003cspan\u003eBPC-157 Vial\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e in parallel tissue repair and cytoprotection endpoints.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3 dir=\"ltr\"\u003e\u003cspan\u003eGH\/IGF Axis Research - Upstream and Downstream\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eIGF-1 LR3 is the primary tool for studying the \u003c\/span\u003e\u003cspan\u003edownstream effector arm of the GH\/IGF somatotropic axis\u003c\/span\u003e\u003cspan\u003e independently of upstream GH secretion. This is critical for studies that need to dissociate the GH-dependent components of somatotropic axis activity from IGF-1R-mediated signalling - such as experiments examining whether a particular biological effect is attributable to GH acting directly on GH receptors or to GH-stimulated IGF-1 acting on IGF-1R.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eResearchers building complete GH\/IGF axis models can combine IGF-1 LR3 (downstream IGF-1R agonism) with our \u003c\/span\u003e\u003ca href=\"https:\/\/heliopeptides.com\/products\/sermorelin-5mg-vial\"\u003e\u003cspan\u003eSermorelin 5MG Vial\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e (GHRH receptor agonism, upstream pituitary GH stimulation), our \u003c\/span\u003e\u003ca href=\"https:\/\/heliopeptides.com\/products\/cjc-1295-dac-vial\"\u003e\u003cspan\u003eCJC-1295 (with DAC) Vial\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e (extended half-life GHRH analogue), or our \u003c\/span\u003e\u003ca href=\"https:\/\/heliopeptides.com\/products\/ipamorelin-vial\"\u003e\u003cspan\u003eIpamorelin Vial\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e (GHSR agonist for GH pulse amplification) - covering the complete signalling cascade from hypothalamic GHRH to pituitary GH secretion to peripheral IGF-1R activation in a systematic research programme.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3 dir=\"ltr\"\u003e\u003cspan\u003eTissue Repair and Regeneration Research\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eThe IGF-1 axis plays a documented role in tissue repair - specifically in the proliferation and differentiation of satellite cells (muscle), chondrocytes (cartilage), tenocytes (tendon), fibroblasts (connective tissue), and neuronal precursors. IGF-1 LR3 is used in tissue repair research to characterise the contribution of IGF-1R signalling to regenerative cell behaviour in injury model systems. Researchers combining IGF-1 LR3's anabolic and proliferative signalling research with tissue repair endpoints may also be working with our \u003c\/span\u003e\u003ca href=\"https:\/\/heliopeptides.com\/products\/bpc-157-vial\"\u003e\u003cspan\u003eBPC-157 Vial\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e and \u003c\/span\u003e\u003ca href=\"https:\/\/heliopeptides.com\/products\/tb-500-vial\"\u003e\u003cspan\u003eTB-500 5MG Vial\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e in parallel injury and recovery model systems - both widely studied in tendon, muscle, and connective tissue repair research alongside growth factor signalling compounds.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3 dir=\"ltr\"\u003e\u003cspan\u003eAgeing and Somatopause Research\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eThe age-related decline in GH pulsatility and IGF-1 production - collectively termed somatopause - is a well-characterised feature of mammalian ageing with documented effects on muscle mass, bone density, adiposity, and cognitive function. IGF-1 LR3 is used in ageing research to characterise the consequences of reduced IGF-1 axis activity on cell and tissue function, and to examine whether restoration of IGF-1R signalling in aged model systems reverses ageing-associated phenotypes. Researchers building multi-faceted ageing biology programmes may combine IGF-1 LR3's axis research with our \u003c\/span\u003e\u003ca href=\"https:\/\/heliopeptides.com\/products\/mots-c-10mg-vial\"\u003e\u003cspan\u003eMOTS-c 10MG Vial\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e for mitochondrial ageing models, our \u003c\/span\u003e\u003ca href=\"https:\/\/heliopeptides.com\/products\/epithalon-vial\"\u003e\u003cspan\u003eEpithalon 10MG Vial\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e for telomere biology, and our \u003c\/span\u003e\u003ca href=\"https:\/\/heliopeptides.com\/products\/thymosin-alpha-1-5mg-vial\"\u003e\u003cspan\u003eThymosin Alpha 1 5MG Vial\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e for immunosenescence research - covering complementary hallmarks of ageing from distinct mechanistic angles.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003ch2 dir=\"ltr\"\u003e\u003cspan\u003eProduct Specifications\u003c\/span\u003e\u003c\/h2\u003e\n\u003cdiv dir=\"ltr\" align=\"left\"\u003e\n\u003ctable\u003e\n\u003ccolgroup\u003e\n\u003ccol width=\"213\"\u003e\n\u003ccol width=\"411\"\u003e\n\u003c\/colgroup\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eSpecification\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eDetail\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003ePeptide Name\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eIGF-1 LR3 (Long R3 Insulin-like Growth Factor-1)\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eAlso Known As\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eLong R3 IGF-1, LR3-IGF-1, IGF-1 Long R3\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eCAS Number\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003e206730-73-6\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eMolecular Formula\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eC₄₀₀H₆₂₅N₁₁₁O₁₁₅S₉\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eMolecular Weight\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003e9,111.46 g\/mol\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eAmino Acid Count\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003e83 amino acids\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eModifications vs IGF-1\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003e13 aa N-terminal extension + Glu→Arg substitution at position 3\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eReceptor Target\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eIGF-1 Receptor (IGF-1R) - receptor tyrosine kinase\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eIGFBP Affinity\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003e~1,000-fold reduced vs native IGF-1 (key research advantage)\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eHalf-life\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003e~20–30 hours in vitro (vs ~12–15h for native IGF-1)\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003ePotency vs IGF-1\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003e~2–3x greater in standard cell culture conditions\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eVial Size\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003e1MG lyophilised powder\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eSynthesis Method\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eSolid-phase peptide synthesis (SPPS)\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003ePurity\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003e≥99% - HPLC and mass spectrometry confirmed\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eTesting Facility\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eISO 17025-accredited third-party laboratory\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eManufacture\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eUSA - controlled facility\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eShort-Term Storage\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eRefrigerate at 4°C (39°F) - days to weeks\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eLong-Term Storage\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eFreeze at -80°C (-112°F) - months to years\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eReconstitution\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003e0.1–1% acetic acid, then dilute in sterile PBS or buffer - research use only\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eSolubility\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eSoluble in dilute acetic acid; moderate aqueous solubility at neutral pH\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003ePrice (Single)\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003e$59.95\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003ePrice (Pack of 10)\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003e$53.96 per vial - 10% saving\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eIntended Use\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eLaboratory research only. Not for human or animal consumption.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003cp dir=\"ltr\"\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003ch2 dir=\"ltr\"\u003e\u003cspan\u003ePurity Testing \u0026amp; Certificate of Analysis\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eEvery batch of Helio Peptides IGF-1 LR3 is independently tested before release. Not sampled - \u003c\/span\u003e\u003cspan\u003eevery batch\u003c\/span\u003e\u003cspan\u003e. Testing is conducted by an ISO 17025-accredited third-party laboratory:\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eHPLC (High-Performance Liquid Chromatography): \u003c\/span\u003e\u003cspan\u003eSeparates and quantifies the 83-amino acid peptide against certified reference standards - confirms identity, detects synthesis by-products and truncated sequences, verifies purity at ≥99%\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eMass Spectrometry (MS): \u003c\/span\u003e\u003cspan\u003eConfirms the exact molecular mass at 9,111.46 g\/mol - verifies the full 83-amino acid sequence including the N-terminal extension and R3 substitution. At this molecular weight, MS is the definitive tool for ruling out sequence errors and incomplete synthesis products\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eAssay \/ Content Testing: \u003c\/span\u003e\u003cspan\u003eConfirms the exact quantity of active IGF-1 LR3 per vial matches the labelled 1MG\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp style=\"box-sizing: border-box; margin-block: 0px 0.9rem; color: rgb(41, 46, 76); font-family: 'Kumbh Sans', sans-serif; font-size: 16px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: rgb(255, 255, 255); text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;\"\u003e\u003cb\u003e\u003cbr\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eThe COA for any specific batch is available on request. Email \u003c\/span\u003e\u003cspan\u003einfo@heliopeptides.com\u003c\/span\u003e\u003cspan\u003e with your order number and batch details. For full COA methodology and guidance on reading HPLC and MS data for large peptides, visit our \u003c\/span\u003e\u003ca href=\"https:\/\/heliopeptides.com\/certificate-of-analysis\"\u003e\u003cspan\u003eCertificate of Analysis and Testing page\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e. Reconstitution and handling protocols are covered on our \u003c\/span\u003e\u003ca href=\"https:\/\/heliopeptides.com\/faq\"\u003e\u003cspan\u003eFAQ page\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003ch2 dir=\"ltr\"\u003e\u003cspan\u003eHow to Reconstitute IGF-1 LR3\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eIGF-1 LR3 requires more careful reconstitution than smaller, highly water-soluble peptides. At 9,111 g\/mol, its solubility at neutral pH is moderate - \u003c\/span\u003e\u003cspan\u003edilute acetic acid is the standard reconstitution vehicle\u003c\/span\u003e\u003cspan\u003e used in published research protocols.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp style=\"box-sizing: border-box; margin-block: 0px 0.9rem; color: rgb(41, 46, 76); font-family: 'Kumbh Sans', sans-serif; font-size: 16px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: rgb(255, 255, 255); text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;\"\u003e\u003cb\u003e\u003cbr\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003col\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eAllow the vial to reach room temperature before opening\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003ePrepare a 0.1–1% acetic acid solution in sterile water (10–100 µL of glacial acetic acid per 10 mL sterile water, filtered through a 0.22 µm membrane)\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eAdd 200–500 µL of the acetic acid solution slowly along the inner wall of the vial\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eGently swirl in a circular motion until fully dissolved - do not shake or vortex. The solution may require 10–15 minutes of gentle rotation for complete dissolution at this molecular weight\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eOnce fully dissolved, dilute to the target working concentration in sterile PBS (pH 7.4) or appropriate cell culture buffer - bringing the final acetic acid concentration to ≤0.1% to avoid pH-related cell toxicity in culture assays\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eInspect the solution - it should be clear and colourless. Discard if cloudiness or particulates are visible\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eAliquot into single-use volumes and store at -80°C immediately, or use within 24–48 hours at 4°C. IGF-1 LR3 loses activity in solution over time - aliquoting prevents degradation from repeated freeze-thaw\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp style=\"box-sizing: border-box; margin-block: 0px 0.9rem; color: rgb(41, 46, 76); font-family: 'Kumbh Sans', sans-serif; font-size: 16px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: rgb(255, 255, 255); text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;\"\u003e\u003cb\u003e\u003cbr\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eBSA (bovine serum albumin, 0.1%) can be added to the reconstitution buffer to prevent adsorption of the peptide to plastic surfaces at low concentrations - a standard practice for growth factor stocks in research settings. For complete handling guidance, visit our \u003c\/span\u003e\u003ca href=\"https:\/\/heliopeptides.com\/faq\"\u003e\u003cspan\u003eFAQ page\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003ch2 dir=\"ltr\"\u003e\u003cspan\u003eStorage Guidelines\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eIGF-1 LR3 is sensitive to repeated freeze-thaw cycles and to adsorption on plastic surfaces at low concentrations. Both are addressable through proper aliquoting and carrier protein use.\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eOn delivery: \u003c\/span\u003e\u003cspan\u003eplace in cold storage immediately - do not leave at room temperature\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eLyophilised vial (short-term): \u003c\/span\u003e\u003cspan\u003erefrigerate at 4°C, away from direct light\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eLyophilised vial (long-term): \u003c\/span\u003e\u003cspan\u003efreeze at -80°C - optimal for extended stability of the 83-amino acid structure\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eReconstituted stock: \u003c\/span\u003e\u003cspan\u003ealiquot immediately into single-use volumes before freezing at -80°C - do not store reconstituted IGF-1 LR3 at 4°C for more than 24–48 hours due to progressive loss of biological activity in solution\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eAvoid repeated freeze-thaw cycles: \u003c\/span\u003e\u003cspan\u003eeach cycle causes measurable loss of IGF-1 LR3 biological activity - single-use aliquots are essential for reproducible research\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003ePlastic adsorption: \u003c\/span\u003e\u003cspan\u003eat concentrations below 100 ng\/mL, add 0.1% BSA to working solutions to prevent peptide adsorption to polypropylene and polystyrene surfaces\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp style=\"box-sizing: border-box; margin-block: 0px 0.9rem; color: rgb(41, 46, 76); font-family: 'Kumbh Sans', sans-serif; font-size: 16px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: rgb(255, 255, 255); text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;\"\u003e\u003cb\u003e\u003cbr\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eHelio Peptides ships all vials with cold-chain packaging. Contact \u003c\/span\u003e\u003cspan\u003einfo@heliopeptides.com\u003c\/span\u003e\u003cspan\u003e or call \u003c\/span\u003e\u003cspan\u003e1-855-435-4633\u003c\/span\u003e\u003cspan\u003e immediately if you have any concerns about vial condition upon arrival.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003ch2 dir=\"ltr\"\u003e\u003cspan\u003eThe Dosing Breakdown\u003c\/span\u003e\u003c\/h2\u003e\n\u003cdiv dir=\"ltr\" align=\"left\"\u003e\n\u003ctable\u003e\n\u003ccolgroup\u003e\n\u003ccol width=\"233\"\u003e\n\u003ccol width=\"391\"\u003e\n\u003c\/colgroup\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eFormat\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eDetail\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eVial size\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003e1MG lyophilised IGF-1 LR3\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eSingle vial price\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003e$59.95\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003ePack of 10 price\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003e$53.96 per vial - 10% saving - $539.60 total\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eTotal in pack of 10\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003e10MG IGF-1 LR3 across 10 vials\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eIn vitro working range\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003e1–100 ng\/mL in cell culture - 1MG provides extensive experimental capacity\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eBest for\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eIGF-1R signalling research, cell proliferation studies, GH\/IGF axis research, cancer biology, skeletal muscle research\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003cp style=\"box-sizing: border-box; margin-block: 0px 0.9rem; color: rgb(41, 46, 76); font-family: 'Kumbh Sans', sans-serif; font-size: 16px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: rgb(255, 255, 255); text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;\"\u003e\u003cb\u003e\u003cbr\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eAt typical cell culture working concentrations of 10–100 ng\/mL, a single 1MG vial reconstituted in 1 mL provides a 1 mg\/mL (1,000,000 ng\/mL) stock - sufficient for thousands of individual well treatments across multiple experimental replicates. Proper aliquoting and storage are essential to realise this experimental capacity. For research programmes requiring consistent batch-matched supply, the pack of ten at $53.96 per vial is the most cost-efficient format. For institutional pricing, contact our \u003c\/span\u003e\u003ca href=\"https:\/\/heliopeptides.com\/wholesale\"\u003e\u003cspan\u003ewholesale team\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003ch2 dir=\"ltr\"\u003e\u003cspan\u003eHow IGF-1 LR3 Fits the Helio Lineup\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eWhen to choose IGF-1 LR3: \u003c\/span\u003e\u003cspan\u003eYour research involves IGF-1 receptor signalling, PI3K\/Akt\/mTOR pathway biology, skeletal muscle cell biology, cell proliferation and survival research, cancer biology IGF axis studies, or downstream GH\/IGF axis characterisation. IGF-1 LR3 is the standard form of IGF-1 for cell culture and in vivo research due to its reduced IGFBP affinity and extended half-life.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eWhen to also consider Sermorelin: \u003c\/span\u003e\u003cspan\u003eOur \u003c\/span\u003e\u003ca href=\"https:\/\/heliopeptides.com\/products\/sermorelin-5mg-vial\"\u003e\u003cspan\u003eSermorelin 5MG Vial\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e is the GHRH receptor agonist for studying the upstream GH stimulation step - use Sermorelin when your research requires characterisation of the hypothalamic-pituitary end of the axis before examining downstream IGF-1R signalling with IGF-1 LR3.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eWhen to also consider CJC-1295: \u003c\/span\u003e\u003cspan\u003eOur \u003c\/span\u003e\u003ca href=\"https:\/\/heliopeptides.com\/products\/cjc-1295-dac-vial\"\u003e\u003cspan\u003eCJC-1295 (with DAC) Vial\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e provides extended GHRH receptor stimulation for sustained GH secretion studies - pair with IGF-1 LR3 for studies examining whether continuous versus pulsatile GH axis activation produces different downstream IGF-1R signalling profiles.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eWhen to also consider Ipamorelin: \u003c\/span\u003e\u003cspan\u003eOur \u003c\/span\u003e\u003ca href=\"https:\/\/heliopeptides.com\/products\/ipamorelin-vial\"\u003e\u003cspan\u003eIpamorelin Vial\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e is the selective GHSR agonist for GH pulse amplification studies - frequently combined with GHRH analogues and paired with downstream IGF-1 LR3 research to characterise the full axis response.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eWhen to also consider AOD-9604: \u003c\/span\u003e\u003cspan\u003eOur \u003c\/span\u003e\u003ca href=\"https:\/\/heliopeptides.com\/products\/aod-9604-vial\"\u003e\u003cspan\u003eAOD-9604 Vial\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e is the GH fragment (176–191) studied specifically for lipolytic effects in adipose tissue - a GH-derived compound that, unlike IGF-1 LR3, does not activate the IGF-1R. Combining AOD-9604 (direct GH receptor lipolytic effects) with IGF-1 LR3 (IGF-1R-mediated anabolic effects) allows dissection of the independent GH and IGF-1 contributions to body composition outcomes.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eWhen to also consider TB-500 or BPC-157: \u003c\/span\u003e\u003cspan\u003eFor tissue repair programmes combining IGF-1R anabolic signalling research with regenerative peptide biology, our \u003c\/span\u003e\u003ca href=\"https:\/\/heliopeptides.com\/products\/tb-500-vial\"\u003e\u003cspan\u003eTB-500 5MG Vial\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e and \u003c\/span\u003e\u003ca href=\"https:\/\/heliopeptides.com\/products\/bpc-157-vial\"\u003e\u003cspan\u003eBPC-157 Vial\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e are the most studied companion peptides in skeletal muscle, tendon, and connective tissue repair model systems.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eWhen to also consider MOTS-c: \u003c\/span\u003e\u003cspan\u003eFor metabolic programmes combining IGF-1R anabolic research with AMPK-mediated metabolic signalling, our \u003c\/span\u003e\u003ca href=\"https:\/\/heliopeptides.com\/products\/mots-c-10mg-vial\"\u003e\u003cspan\u003eMOTS-c 10MG Vial\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e provides the mitochondria-to-nucleus AMPK activation axis - a complementary metabolic signalling pathway to IGF-1R\/PI3K\/Akt\/mTOR biology.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003ch2 dir=\"ltr\"\u003e\u003cspan\u003eShipping \u0026amp; Fulfilment\u003c\/span\u003e\u003c\/h2\u003e\n\u003cdiv dir=\"ltr\" align=\"left\"\u003e\n\u003ctable\u003e\n\u003ccolgroup\u003e\n\u003ccol width=\"200\"\u003e\n\u003ccol width=\"424\"\u003e\n\u003c\/colgroup\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eDetail\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003ePolicy\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eSame-Day Dispatch\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eOrders placed before the daily cut-off ship same day from our US facility\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eFree Shipping\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eOn all orders over $100\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eDomestic Delivery\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003e1–3 business days within the USA\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eCold-Chain Packaging\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eAll vials ship with cold-chain protection to maintain peptide integrity in transit\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003ePayment Methods\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eCredit\/debit card (3D Secure), bank transfer, ETH, BTC, USDC\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eCustomer Service\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003e1-855-435-4633  ·  info@heliopeptides.com  ·  Live Chat on site\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003cp dir=\"ltr\"\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003ch2 dir=\"ltr\"\u003e\u003cspan\u003eFrequently Asked Questions\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eWhat is IGF-1 LR3 used for in research?\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eIGF-1 LR3 is studied in controlled laboratory settings for IGF-1 receptor signalling and PI3K\/Akt\/mTOR pathway research, skeletal muscle cell biology, cell proliferation and survival signalling, cancer biology IGF axis studies, tissue repair and regeneration models, GH\/IGF axis downstream characterisation, and ageing\/somatopause research. Research use only - not for human or animal consumption.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eWhat is the difference between IGF-1 LR3 and native IGF-1?\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eIGF-1 LR3 has two modifications versus native IGF-1: a 13-amino acid N-terminal extension and a Glu→Arg substitution at position 3. Together these reduce IGFBP (IGF binding protein) affinity approximately 1,000-fold, while maintaining full IGF-1R binding affinity. The result is approximately 2–3x greater potency in standard cell culture conditions (where native IGF-1 activity is attenuated by serum-borne IGFBPs) and an extended half-life of approximately 20–30 hours versus 12–15 hours for native IGF-1.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eWhat is the difference between IGF-1 LR3 and IGF-1 DES?\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eIGF-1 LR3 is an 83-amino acid analogue engineered for systemic, extended-duration IGF-1R signalling with reduced IGFBP affinity. Our \u003c\/span\u003e\u003ca href=\"https:\/\/heliopeptides.com\/products\/igf-1-des-vial\"\u003e\u003cspan\u003eIGF-1 DES Vial\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e is a truncated 67-amino acid form lacking the first 3 N-terminal amino acids of native IGF-1, with very low IGFBP affinity and very short half-life - producing intense, localised IGF-1R activation. LR3 is preferred for systemic and sustained signalling studies; DES is preferred for studies requiring intense local receptor activation with rapid clearance.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eWhat is the molecular weight of IGF-1 LR3?\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003e9,111.46 g\/mol. Molecular formula C₄₀₀H₆₂₅N₁₁₁O₁₁₅S₉. CAS number 206730-73-6. 83-amino acid synthetic analogue of human IGF-1 with N-terminal extension and R3 substitution.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eHow do I reconstitute IGF-1 LR3?\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eReconstitute in 0.1–1% acetic acid solution (200–500 µL per vial), gently swirling for 10–15 minutes - do not shake. Then dilute to working concentration in sterile PBS (pH 7.4). Add 0.1% BSA to working solutions below 100 ng\/mL to prevent adsorption to plastic surfaces. Full protocol on our \u003c\/span\u003e\u003ca href=\"https:\/\/heliopeptides.com\/faq\"\u003e\u003cspan\u003eFAQ page\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eHow should I store IGF-1 LR3?\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eLyophilised vial: -80°C long-term, 4°C short-term. Once reconstituted: aliquot immediately and freeze at -80°C - do not store reconstituted solution at 4°C for more than 24–48 hours. Avoid all repeated freeze-thaw cycles - biological activity loss per cycle is significant. Use single-use aliquots for every experiment.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eIs every batch of IGF-1 LR3 third-party tested?\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eYes - every batch. ISO 17025-accredited laboratory testing confirms identity by HPLC, molecular weight at 9,111.46 g\/mol by MS, and assay content at 1MG. Visit our \u003c\/span\u003e\u003ca href=\"https:\/\/heliopeptides.com\/certificate-of-analysis\"\u003e\u003cspan\u003eCertificate of Analysis page\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e or email info@heliopeptides.com to request your batch COA.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eWhy does IGF-1 LR3 perform better than native IGF-1 in cell culture?\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eStandard cell culture media contains serum (typically 5–20% FBS or FCS), which contains endogenous IGF-binding proteins (IGFBPs) that compete with IGF-1 receptors for IGF-1 binding and sequester a significant fraction of added native IGF-1 away from the receptor. IGF-1 LR3's ~1,000-fold reduced IGFBP affinity means it is not sequestered - the dose delivered to the receptor is the dose added to the medium, producing dose-response relationships that are approximately 2–3x more potent and significantly more reproducible than native IGF-1 in the same conditions.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eWhat signalling pathway does IGF-1 LR3 activate?\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eIGF-1 LR3 binds IGF-1R (receptor tyrosine kinase), triggering receptor autophosphorylation, IRS-1 recruitment, PI3K activation, Akt phosphorylation (Thr308 and Ser473), mTORC1 activation (p70S6K phosphorylation, 4E-BP1 phosphorylation), and downstream protein synthesis, cell proliferation, and anti-apoptotic signalling. It also activates the MAPK\/ERK pathway through SHC\/Grb2\/SOS\/Ras signalling. These are the standard readouts for IGF-1R activation studies.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eWhere is Helio Peptides IGF-1 LR3 manufactured?\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eSynthesised in the United States by solid-phase peptide synthesis (SPPS) in a controlled US-based facility. USA made, USA tested, shipped same day with cold-chain packaging.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eHow does IGF-1 LR3 relate to GH secretagogue research?\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eIGF-1 LR3 is the downstream effector of the GH\/IGF axis - GH stimulates IGF-1 production in the liver and other tissues, which then acts on IGF-1R. Studies using our \u003c\/span\u003e\u003ca href=\"https:\/\/heliopeptides.com\/products\/sermorelin-5mg-vial\"\u003e\u003cspan\u003eSermorelin 5MG Vial\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e or \u003c\/span\u003e\u003ca href=\"https:\/\/heliopeptides.com\/products\/ipamorelin-vial\"\u003e\u003cspan\u003eIpamorelin Vial\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e to stimulate upstream GH secretion can be paired with IGF-1 LR3 studies to characterise whether observed downstream effects are mediated through IGF-1R signalling or through direct GH receptor activation.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eDoes Helio Peptides ship internationally?\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eContact info@heliopeptides.com or call 1-855-435-4633 for current international shipping availability. Domestic US orders: same-day dispatch, 1–3 business day delivery.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eWhat payment methods are accepted?\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eCredit\/debit card (3D Secure), bank transfer, Ethereum (ETH), Bitcoin (BTC), and USDC at locked exchange rates.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eIs IGF-1 LR3 legal to buy in the USA?\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eIGF-1 LR3 is sold as a research chemical for laboratory use only. It is not a scheduled controlled substance in the United States and is not FDA-approved for human use. All purchases must comply with applicable federal and state laws. Buyers confirm research intent at checkout.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eWhat does the Certificate of Analysis include?\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eBatch number, testing date, ISO 17025 facility credentials, HPLC chromatogram confirming identity and purity at ≥99%, mass spectrometry data confirming molecular weight at 9,111.46 g\/mol, and assay result confirming 1MG content. Request via our \u003c\/span\u003e\u003ca href=\"https:\/\/heliopeptides.com\/certificate-of-analysis\"\u003e\u003cspan\u003eCertificate of Analysis page\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e or email info@heliopeptides.com with your order number.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eIs there a bulk discount on IGF-1 LR3?\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eYes. Pack of 10 at $53.96 per vial - 10% saving over $59.95 single price, $539.60 total for 10MG. For institutional or wholesale quantities, contact \u003c\/span\u003e\u003ca href=\"https:\/\/heliopeptides.com\/wholesale\"\u003e\u003cspan\u003eour wholesale team\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003ch2 dir=\"ltr\"\u003e\u003cspan\u003eExplore More From Helio Peptides\u003c\/span\u003e\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003ca href=\"https:\/\/heliopeptides.com\/products\/sermorelin-5mg-vial\"\u003e\u003cspan\u003eSermorelin 5MG Vial\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e - GHRH receptor agonist, upstream GH axis research\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003ca href=\"https:\/\/heliopeptides.com\/products\/cjc-1295-dac-vial\"\u003e\u003cspan\u003eCJC-1295 (with DAC) Vial\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e - extended half-life GHRH analogue, sustained GH stimulation research\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003ca href=\"https:\/\/heliopeptides.com\/products\/ipamorelin-vial\"\u003e\u003cspan\u003eIpamorelin Vial\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e - selective GHSR agonist, GH pulse amplification research\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003ca href=\"https:\/\/heliopeptides.com\/products\/aod-9604-vial\"\u003e\u003cspan\u003eAOD-9604 Vial\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e - GH fragment 176–191, lipolysis and adipose tissue research\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003ca href=\"https:\/\/heliopeptides.com\/products\/igf-1-des-vial\"\u003e\u003cspan\u003eIGF-1 DES Vial\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e - truncated IGF-1, intense local IGF-1R activation research\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003ca href=\"https:\/\/heliopeptides.com\/products\/tb-500-vial\"\u003e\u003cspan\u003eTB-500 5MG Vial\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e - thymosin beta-4 fragment, tissue repair and regeneration research\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003ca href=\"https:\/\/heliopeptides.com\/products\/bpc-157-vial\"\u003e\u003cspan\u003eBPC-157 Vial\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e - GI tract, tendon, and systemic repair research\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003ca href=\"https:\/\/heliopeptides.com\/products\/mots-c-10mg-vial\"\u003e\u003cspan\u003eMOTS-c 10MG Vial\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e - mitochondrial-derived peptide, AMPK pathway, metabolic research\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003ca href=\"https:\/\/heliopeptides.com\/products\/slu-pp-332-5mg-vial\"\u003e\u003cspan\u003eSLU-PP-332 5MG Vial\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e - pan-ERR agonist, mitochondrial biogenesis and exercise biology research\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003ca href=\"https:\/\/heliopeptides.com\/products\/epithalon-vial\"\u003e\u003cspan\u003eEpithalon 10MG Vial\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e - longevity, telomere, and ageing biology research\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003ca href=\"https:\/\/heliopeptides.com\/products\/thymosin-alpha-1-5mg-vial\"\u003e\u003cspan\u003eThymosin Alpha 1 5MG Vial\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e - immune modulation and antiviral research\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003ca href=\"https:\/\/heliopeptides.com\/wholesale\"\u003e\u003cspan\u003eWholesale \u0026amp; Bulk Orders\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e - institutional pricing for research programmes requiring consistent supply\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp dir=\"ltr\"\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eAll products sold on heliopeptides.com are intended solely for laboratory research and are not for human or animal consumption. These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease. By purchasing, the buyer confirms they are a qualified researcher and agrees to comply with all applicable federal and state laws. Not for sale to persons under the age of 21.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp style=\"box-sizing: border-box; margin-block: 0px 0.9rem; color: rgb(41, 46, 76); font-family: 'Kumbh Sans', sans-serif; font-size: 16px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: rgb(255, 255, 255); text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;\"\u003e \u003c\/p\u003e","brand":"heliopeptides","offers":[{"title":"Default Title","offer_id":49030620578035,"sku":null,"price":59.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0825\/8791\/0387\/files\/Helio_Vial_IGF-1LR3_1MG_Render.png?v=1778316345","url":"https:\/\/heliopeptides.com\/products\/igf-1-lr3-1mg-vial","provider":"Helio Peptides","version":"1.0","type":"link"}