{"product_id":"pt-141-10mg-vial","title":"PT-141 (Bremelanotide) 10MG Research Vial - Melanocortin Receptor Agonist | Third-Party Tested","description":"\u003ch2 dir=\"ltr\"\u003e\u003cspan\u003ePT-141 Research That Actually Gets Used\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eMelanocortin receptor pharmacology is one of the most actively investigated areas of neuroendocrine research. The compounds used to probe this system need to be precisely characterised - correct sequence, confirmed molecular identity, documented batch. Most research compound suppliers can't demonstrate any of that.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eHelio Peptides operates differently.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eEvery vial of PT-141 goes through \u003c\/span\u003e\u003cspan\u003eindependent third-party testing at an ISO 17025-accredited laboratory\u003c\/span\u003e\u003cspan\u003e before it ships - identity confirmed by HPLC, molecular weight verified by mass spectrometry, and assay content confirmed at the labelled 10MG. The Certificate of Analysis is available on request for every batch. Not selectively. Every batch.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003ePT-141 - also known as Bremelanotide - is a synthetic cyclic heptapeptide and potent agonist of the melanocortin receptor family, developed from the earlier melanocortin agonist Melanotan II. It is one of the most studied melanocortin receptor agonists in the preclinical and clinical research literature, with a documented pharmacological profile across MC1R, MC3R, MC4R, and MC5R receptor subtypes. At $39.95 per vial - or $35.96 in a pack of ten - it is among the most cost-accessible and thoroughly documented melanocortin research compounds available from a US-based, ISO-accredited tested supplier. Researchers working across the melanocortin receptor system may also be investigating our \u003c\/span\u003e\u003ca href=\"https:\/\/heliopeptides.com\/products\/melanotan-2-vial\"\u003e\u003cspan\u003eMelanotan II Vial\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e - the linear precursor peptide from which PT-141 was developed - alongside PT-141 in comparative receptor subtype selectivity studies.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 dir=\"ltr\"\u003e\u003cspan\u003eWhat Makes This Vial Different\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003ePT-141 is available from multiple research compound suppliers. The meaningful question is not availability - it's verification. Here's what separates the Helio Peptides PT-141 10MG vial:\u003c\/span\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eThird-party tested at an ISO 17025-accredited lab.\u003c\/span\u003e\u003cspan\u003e  The laboratory conducting the testing has been independently verified for technical accuracy and measurement reliability. Every Helio Peptides PT-141 batch is tested at such a facility. Full batch documentation is available in our \u003c\/span\u003e\u003ca href=\"https:\/\/heliopeptides.com\/certificate-of-analysis\"\u003e\u003cspan\u003eCertificate of Analysis\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eUSA manufactured.\u003c\/span\u003e\u003cspan\u003e  Synthesised by solid-phase peptide synthesis (SPPS) in a controlled US-based facility under strict manufacturing standards. Not imported bulk material relabelled domestically - manufactured, tested, and dispatched from the United States.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eSequence and structure confirmed by mass spectrometry.\u003c\/span\u003e\u003cspan\u003e  PT-141 is a cyclic heptapeptide - its cyclic structure (formed by a lactam bridge between Asp and Lys residues) is confirmed at every batch by MS. Cyclic peptide synthesis is more technically demanding than linear synthesis - confirmation of cyclisation and the correct disulfide-equivalent bridge is essential for receptor activity.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eLyophilised for stability.\u003c\/span\u003e\u003cspan\u003e  Supplied as lyophilised powder - substantially more stable than liquid formats in shipping and storage. Cold-chain packaging included on every order.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eCost-accessible with a bulk option.\u003c\/span\u003e\u003cspan\u003e  $39.95 single vial. $35.96 per vial in a pack of ten. Competitive pricing for ISO-accredited tested PT-141 from a US supplier with same-day dispatch.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 dir=\"ltr\"\u003e\u003cspan\u003eWhat Is PT-141 (Bremelanotide)?\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003ePT-141, formally known as Bremelanotide, is a synthetic cyclic heptapeptide melanocortin receptor agonist developed as a metabolite of Melanotan II (MT-II). Its full chemical name is cyclo(-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys])2 with the systematic name (3S,6R,9S,12S,15R,18S,21R)-15-(4-aminobutyl)-9-benzyl-6-[3-(diaminomethylideneamino)propyl]-12-(1H-imidazol-5-ylmethyl)-3-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-18-(propan-2-yl)-1,4,7,10,13,16,19-heptazacyclotricosane-21-carboxamide.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003ePT-141 was identified as an active metabolite when Melanotan II was metabolised in vivo to the des-glycine form. This metabolite retained melanocortin receptor agonist activity while exhibiting a distinct pharmacological profile from the parent compound. Unlike Melanotan II - which is a linear peptide - PT-141 is a cyclic lactam structure, conferring greater metabolic stability and a different receptor subtype selectivity profile.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003ePT-141 acts as an agonist at multiple melanocortin receptor subtypes - specifically \u003c\/span\u003e\u003cspan\u003eMC1R, MC3R, MC4R, and MC5R\u003c\/span\u003e\u003cspan\u003e - with particularly well-characterised activity at MC4R and MC3R. The melanocortin system is a neuroendocrine signalling network governing a remarkably broad range of physiological functions including pigmentation (MC1R), energy homeostasis and body weight (MC3R, MC4R), central nervous system autonomic pathways (MC4R), and exocrine gland function (MC5R). PT-141's pan-melanocortin receptor activity makes it a versatile pharmacological tool for studying melanocortin receptor biology across multiple organ systems and physiological contexts.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003ePT-141 differs from Melanotan II primarily in its cyclic structure and consequent receptor selectivity profile. Our \u003c\/span\u003e\u003ca href=\"https:\/\/heliopeptides.com\/products\/melanotan-2-vial\"\u003e\u003cspan\u003eMelanotan II Vial\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e is the linear parent compound - active at MC1R, MC3R, MC4R, and MC5R with a slightly different potency distribution across receptor subtypes. Researchers conducting comparative melanocortin pharmacology will frequently work with both PT-141 and Melanotan II in parallel to characterise receptor subtype selectivity, structural determinants of binding affinity, and the pharmacodynamic consequences of cyclic versus linear peptide presentation at melanocortin receptors.\u003c\/span\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cdiv dir=\"ltr\" align=\"left\"\u003e\n\u003ctable\u003e\n\u003ccolgroup\u003e\u003ccol width=\"624\"\u003e\u003c\/colgroup\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003e\"PT-141 (Bremelanotide) is one of the most comprehensively studied melanocortin receptor agonists in the preclinical literature - with documented activity across MC1R, MC3R, MC4R, and MC5R, a well-characterised pharmacokinetic profile, and a published clinical research record. Its cyclic structure, metabolic stability, and pan-MCR activity make it indispensable for any laboratory conducting systematic melanocortin receptor pharmacology.\"\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003e- Melanocortin research community on PT-141 as a reference standard\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003cp dir=\"ltr\"\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003ch2 dir=\"ltr\"\u003e\u003cspan\u003eResearch Applications\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003ePT-141 has been investigated across a broad range of research directions in melanocortin receptor pharmacology, neuroendocrinology, and autonomic nervous system research. All applications described below are for controlled laboratory environments only. This product is for research use only and is not for human or animal consumption.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3 dir=\"ltr\"\u003e\u003cspan\u003eMelanocortin Receptor Pharmacology\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eThe foundational research application for PT-141 is systematic characterisation of melanocortin receptor subtypes. The melanocortin receptor family comprises five G-protein-coupled receptors (MC1R–MC5R) with distinct tissue distributions, endogenous ligand profiles, and physiological functions. PT-141's activity across MC1R, MC3R, MC4R, and MC5R - combined with its well-defined pharmacokinetic profile - makes it a reference compound for \u003c\/span\u003e\u003cspan\u003emelanocortin receptor binding assays, signal transduction studies, and receptor selectivity characterisation\u003c\/span\u003e\u003cspan\u003e in both heterologous expression systems (HEK293, CHO cells) and native tissue preparations.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eResearch in this area includes cAMP accumulation assays (MCR signalling is primarily Gs-coupled), receptor internalisation and trafficking studies, competitive binding assays comparing PT-141 to endogenous melanocortin peptides (α-MSH, β-MSH, γ-MSH, ACTH) and to novel synthetic MCR ligands, and characterisation of species-specific receptor pharmacology across murine, primate, and human MCR sequences.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3 dir=\"ltr\"\u003e\u003cspan\u003eMC4R and Central Nervous System Research\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eMC4R is expressed throughout the central nervous system - particularly in hypothalamic nuclei governing autonomic function, energy balance, and reproductive physiology. PT-141's well-characterised MC4R agonist activity makes it a primary tool for studying \u003c\/span\u003e\u003cspan\u003ehypothalamic MC4R signalling pathways\u003c\/span\u003e\u003cspan\u003e in neuroendocrine research. Published studies have examined PT-141's effects on hypothalamic neuronal activity, autonomic outflow modulation, and the central regulation of peripheral physiological responses through MC4R-expressing neuronal populations. Researchers investigating MC4R signalling in the context of feeding behaviour and energy homeostasis may also be working with our \u003c\/span\u003e\u003ca href=\"https:\/\/heliopeptides.com\/products\/mots-c-vial\"\u003e\u003cspan\u003eMOTS-c 10MG Vial\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e or our \u003c\/span\u003e\u003ca href=\"https:\/\/heliopeptides.com\/products\/aod-9604-vial\"\u003e\u003cspan\u003eAOD-9604 Vial\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e in complementary metabolic research programmes.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3 dir=\"ltr\"\u003e\u003cspan\u003eMC3R and Energy Homeostasis Research\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eMC3R - expressed in hypothalamic nuclei, limbic structures, and peripheral metabolic tissues - is studied for its role in energy homeostasis, adipose tissue biology, and the regulation of energy expenditure. PT-141's MC3R agonist activity has made it a tool for studying the contribution of MC3R signalling to appetite regulation, adiposity phenotypes, and the interaction between the melanocortin system and leptin\/insulin signalling pathways in murine metabolic models.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eResearch examining the melanocortin system's contribution to metabolic syndrome and obesity phenotypes frequently uses PT-141 alongside melanocortin receptor antagonists to establish the directional contribution of MC3R and MC4R signalling to observed metabolic outcomes. Researchers in this domain may also be examining our \u003c\/span\u003e\u003ca href=\"https:\/\/heliopeptides.com\/products\/slu-pp-332-5mg-vial\"\u003e\u003cspan\u003eSLU-PP-332 5MG Vial\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e - the pan-ERR agonist exercise mimetic - for complementary transcriptional metabolic research running alongside melanocortin pharmacology studies.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3 dir=\"ltr\"\u003e\u003cspan\u003eMC1R and Pigmentation Research\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eMC1R is expressed predominantly on melanocytes and governs the switch between eumelanin (brown\/black) and phaeomelanin (red\/yellow) pigment synthesis in response to α-MSH stimulation. PT-141's MC1R agonist activity has made it a tool for studying \u003c\/span\u003e\u003cspan\u003emelanocyte biology, pigmentation pathway regulation, and MC1R signal transduction\u003c\/span\u003e\u003cspan\u003e in cell culture and murine model systems. This includes research on MC1R-mediated cAMP signalling in B16 melanoma cells, MC1R's role in photoprotection responses to UV irradiation, and the characterisation of MC1R variants associated with pigmentation phenotypes. Researchers studying pigmentation biology may also be working with our \u003c\/span\u003e\u003ca href=\"https:\/\/heliopeptides.com\/products\/melanotan-2-vial\"\u003e\u003cspan\u003eMelanotan II Vial\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e in parallel MC1R agonist studies, and with our \u003c\/span\u003e\u003ca href=\"https:\/\/heliopeptides.com\/products\/ghk-cu-vial\"\u003e\u003cspan\u003eGHK-Cu 50MG Vial\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e in complementary melanocyte biology and skin research programmes.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3 dir=\"ltr\"\u003e\u003cspan\u003eAutonomic Nervous System and Cardiovascular Research\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003ePT-141 has been studied in the context of autonomic nervous system modulation - specifically the cardiovascular effects associated with melanocortin receptor agonism in central autonomic control centres. Published research has examined PT-141's effects on blood pressure, heart rate, and autonomic tone in murine models, characterising the cardiovascular pharmacodynamics of systemic melanocortin receptor agonism. This research is relevant to understanding the autonomic side effect profile of melanocortin compounds and to the broader study of central-peripheral autonomic crosstalk through hypothalamic MC4R-expressing neuronal circuits.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3 dir=\"ltr\"\u003e\u003cspan\u003eComparative Melanocortin Agonist Research: PT-141 vs Melanotan II\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eA significant application of PT-141 in research settings is its use in systematic comparative studies alongside our \u003c\/span\u003e\u003ca href=\"https:\/\/heliopeptides.com\/products\/melanotan-2-vial\"\u003e\u003cspan\u003eMelanotan II Vial\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e. The structural relationship between the two compounds - PT-141 as the cyclic des-glycine metabolite of the linear Melanotan II - makes direct comparison valuable for characterising how cyclisation affects receptor subtype selectivity, binding kinetics, metabolic stability, and pharmacodynamic profile across the melanocortin receptor family. Studies comparing PT-141 and Melanotan II have been published across multiple pharmacological endpoints, making the availability of both compounds from a single ISO-tested source a practical advantage for research programmes building systematic melanocortin receptor pharmacology datasets.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 dir=\"ltr\"\u003e\u003cspan\u003eProduct Specifications\u003c\/span\u003e\u003c\/h2\u003e\n\u003cdiv dir=\"ltr\" align=\"left\"\u003e\n\u003ctable\u003e\n\u003ccolgroup\u003e\n\u003ccol width=\"213\"\u003e\n\u003ccol width=\"411\"\u003e\n\u003c\/colgroup\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eSpecification\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eDetail\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003ePeptide Name\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003ePT-141 (Bremelanotide)\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eAlso Known As\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eBremelanotide, cyclo(-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys])\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eCAS Number\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003e189691-06-3\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eMolecular Formula\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eC₅₀H₆₈N₁₄O₁₀\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eMolecular Weight\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003e1,025.17 g\/mol\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eStructure\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eCyclic heptapeptide - lactam bridge between Asp and Lys residues\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eAmino Acid Count\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003e7 amino acids (cyclic lactam structure)\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eReceptor Targets\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eMC1R, MC3R, MC4R, MC5R (pan-melanocortin receptor agonist)\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eMC4R Activity\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003ePrimary CNS melanocortin receptor target - hypothalamic autonomic pathways\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eMC1R Activity\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eMelanocyte pigmentation pathway - eumelanin\/phaeomelanin switch\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eVial Size\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003e10MG lyophilised powder\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eSynthesis Method\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eSolid-phase peptide synthesis (SPPS) with cyclisation\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003ePurity\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003e≥99% - HPLC and mass spectrometry confirmed\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eTesting Facility\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eISO 17025-accredited third-party laboratory\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eManufacture\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eUSA - controlled facility\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eShort-Term Storage\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eRefrigerate at 4°C (39°F) - days to weeks\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eLong-Term Storage\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eFreeze at -80°C (-112°F) - months to years\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eReconstitution\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eBacteriostatic water or sterile water - research use only\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eSolubility\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eSoluble in water; freely soluble in dilute acetic acid\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003ePrice (Single)\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003e$39.95\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003ePrice (Pack of 10)\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003e$35.96 per vial - 10% saving\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eIntended Use\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eLaboratory research only. Not for human or animal consumption.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003cp dir=\"ltr\"\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003ch2 dir=\"ltr\"\u003e\u003cspan\u003ePurity Testing \u0026amp; Certificate of Analysis\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eEvery batch of Helio Peptides PT-141 is independently tested before release. Not sampled - \u003c\/span\u003e\u003cspan\u003eevery batch\u003c\/span\u003e\u003cspan\u003e. Testing is conducted by an ISO 17025-accredited third-party laboratory using three confirmatory analytical methods:\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eHPLC (High-Performance Liquid Chromatography): \u003c\/span\u003e\u003cspan\u003eSeparates and quantifies the compound against certified reference standards - confirms identity, detects synthesis by-products, and verifies purity at ≥99%\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eMass Spectrometry (MS): \u003c\/span\u003e\u003cspan\u003eConfirms the exact molecular mass at 1,025.17 g\/mol and verifies the cyclic lactam structure - rules out linear (uncyclised) synthesis product, truncated sequences, and structural artefacts\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eAssay \/ Content Testing: \u003c\/span\u003e\u003cspan\u003eConfirms the exact quantity of active PT-141 per vial matches the labelled 10MG\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eThe COA for any specific batch is available on request. Email \u003c\/span\u003e\u003cspan\u003einfo@heliopeptides.com\u003c\/span\u003e\u003cspan\u003e with your order number and batch details, or use the live chat on site. For a full explanation of COA methodology, how to interpret HPLC chromatograms, and why ISO 17025 laboratory accreditation matters, visit our \u003c\/span\u003e\u003ca href=\"https:\/\/heliopeptides.com\/certificate-of-analysis\"\u003e\u003cspan\u003eCertificate of Analysis and Testing page\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e. Reconstitution guidance and laboratory handling protocols are covered on our \u003c\/span\u003e\u003ca href=\"https:\/\/heliopeptides.com\/faq\"\u003e\u003cspan\u003eFAQ page\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 dir=\"ltr\"\u003e\u003cspan\u003eHow to Reconstitute PT-141\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003ePT-141 is supplied as a lyophilised powder. It is soluble in water and freely soluble in dilute acetic acid - for vials that require additional solubility assistance, a small volume of dilute acetic acid (0.1–1%) followed by dilution in sterile water or buffer is the standard approach in published research protocols.\u003c\/span\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003col\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eAllow the vial to reach room temperature before opening - prevents moisture condensation on the peptide\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eDraw the required volume of bacteriostatic water or sterile water for injection using a sterile needle and syringe\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eInject the diluent slowly along the inner wall of the vial - not directly onto the lyophilised cake\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eGently swirl in a circular motion until fully dissolved. If resistance is encountered, a small volume of 0.1% acetic acid can be added first, followed by dilution to the target volume in sterile water\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eInspect the solution - it should be clear and colourless. Discard if cloudiness or particulates are visible\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eStore reconstituted solution at 4°C and use within 2–4 weeks, or aliquot and freeze at -80°C\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eFor in vitro receptor binding and cell-based assays, further dilute the reconstituted stock in appropriate assay buffer (typically PBS or HEPES-buffered saline, pH 7.4) to working concentrations. For in vivo murine studies, subcutaneous or intraperitoneal administration in sterile saline vehicle has been used in published protocols. For complete reconstitution and handling guidance, visit our \u003c\/span\u003e\u003ca href=\"https:\/\/heliopeptides.com\/faq\"\u003e\u003cspan\u003eFAQ page\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 dir=\"ltr\"\u003e\u003cspan\u003eStorage Guidelines\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003ePT-141's cyclic structure confers greater metabolic stability than linear peptides of comparable size, but proper storage is still essential to maintain research-grade integrity.\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eOn delivery: \u003c\/span\u003e\u003cspan\u003erefrigerate immediately - do not leave at room temperature for extended periods\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eShort-term (days to weeks): \u003c\/span\u003e\u003cspan\u003erefrigerate at 4°C, away from direct light, in original or opaque packaging\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eLong-term (months to years): \u003c\/span\u003e\u003cspan\u003efreeze at -80°C - optimal for extended stability of the cyclic peptide structure\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eAvoid repeated freeze-thaw cycles: \u003c\/span\u003e\u003cspan\u003ealiquot into single-use volumes before freezing if the vial will be accessed across multiple experimental sessions\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003eReconstituted solution: \u003c\/span\u003e\u003cspan\u003estable at 4°C for 2–4 weeks. Freeze aliquots at -80°C for longer storage\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003cspan\u003epH sensitivity: \u003c\/span\u003e\u003cspan\u003emaintain near-neutral pH in storage solutions - avoid extremes of pH that can hydrolyse the lactam bridge or deamidate residues\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eHelio Peptides ships all vials with cold-chain packaging. Contact \u003c\/span\u003e\u003cspan\u003einfo@heliopeptides.com\u003c\/span\u003e\u003cspan\u003e or call \u003c\/span\u003e\u003cspan\u003e1-855-435-4633\u003c\/span\u003e\u003cspan\u003e immediately if you have any concerns about vial condition upon arrival.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 dir=\"ltr\"\u003e\u003cspan\u003eThe Dosing Breakdown\u003c\/span\u003e\u003c\/h2\u003e\n\u003cdiv dir=\"ltr\" align=\"left\"\u003e\n\u003ctable\u003e\n\u003ccolgroup\u003e\n\u003ccol width=\"233\"\u003e\n\u003ccol width=\"391\"\u003e\n\u003c\/colgroup\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eFormat\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eDetail\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eVial size\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003e10MG lyophilised PT-141 (Bremelanotide)\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eSingle vial price\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003e$39.95\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003ePack of 10 price\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003e$35.96 per vial - 10% saving - $359.60 total\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eTotal in pack of 10\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003e100MG PT-141 across 10 vials\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eBest for\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eMelanocortin receptor pharmacology research, MC4R\/MC3R\/MC1R studies, comparative melanocortin agonist programmes\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003cp style=\"box-sizing: border-box; margin-block: 0px 0.9rem; color: rgb(41, 46, 76); font-family: 'Kumbh Sans', sans-serif; font-size: 16px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; white-space: normal; background-color: rgb(255, 255, 255); text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;\"\u003e\u003cb\u003e\u003cbr\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eThe 10MG vial provides sufficient material for extensive in vitro receptor characterisation work across multiple concentration ranges, and for multi-dose in vivo murine studies when concentration-response relationships are being established. For research programmes requiring consistent batch-matched supply across extended experimental timelines, the pack of ten at $35.96 per vial is the most cost-efficient format. For institutional or wholesale pricing, contact our \u003c\/span\u003e\u003ca href=\"https:\/\/heliopeptides.com\/wholesale\"\u003e\u003cspan\u003ewholesale team\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e directly.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 dir=\"ltr\"\u003e\u003cspan\u003eHow PT-141 Fits the Helio Lineup\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eWhen to choose PT-141: \u003c\/span\u003e\u003cspan\u003eYour research involves melanocortin receptor pharmacology, MC4R or MC3R signalling studies, central autonomic regulation research, MC1R pigmentation biology, or comparative melanocortin agonist programmes requiring a cyclic lactam structure reference compound.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eWhen to also consider Melanotan II: \u003c\/span\u003e\u003cspan\u003eOur \u003c\/span\u003e\u003ca href=\"https:\/\/heliopeptides.com\/products\/melanotan-2-vial\"\u003e\u003cspan\u003eMelanotan II (MT-II) Vial\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e is the linear parent compound from which PT-141 is derived. Comparative studies between PT-141 (cyclic) and Melanotan II (linear) are fundamental to structure-activity relationship research in melanocortin pharmacology. Both compounds are available from Helio Peptides with full ISO-accredited COA documentation.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eWhen to also consider Thymosin Alpha 1: \u003c\/span\u003e\u003cspan\u003eFor multi-peptide research programmes spanning melanocortin and immune biology, our \u003c\/span\u003e\u003ca href=\"https:\/\/heliopeptides.com\/products\/thymosin-alpha-1-5mg-vial\"\u003e\u003cspan\u003eThymosin Alpha 1 5MG Vial\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e covers TLR pathway modulation and T-cell differentiation research - a complementary research thread in neuroimmunology programmes examining melanocortin-immune system interactions.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eWhen to also consider BPC-157: \u003c\/span\u003e\u003cspan\u003eResearchers examining tissue repair endpoints alongside melanocortin receptor pharmacology will find our \u003c\/span\u003e\u003ca href=\"https:\/\/heliopeptides.com\/products\/bpc-157-vial\"\u003e\u003cspan\u003eBPC-157 Vial\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e relevant - BPC-157 has documented interactions with dopaminergic and serotonergic systems that make it of interest in neuromodulation research alongside MCR compounds.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eWhen to also consider GHK-Cu: \u003c\/span\u003e\u003cspan\u003eFor research programmes examining melanocyte biology and skin-related peptide pharmacology alongside PT-141's MC1R research applications, our \u003c\/span\u003e\u003ca href=\"https:\/\/heliopeptides.com\/products\/ghk-cu-vial\"\u003e\u003cspan\u003eGHK-Cu 50MG Vial\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e covers collagen synthesis, skin matrix remodelling, and melanocyte-related wound healing models.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eWhen to also consider KPV: \u003c\/span\u003e\u003cspan\u003eOur \u003c\/span\u003e\u003ca href=\"https:\/\/heliopeptides.com\/products\/kpv-vial\"\u003e\u003cspan\u003eKPV 10MG Vial\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e is the C-terminal tripeptide of α-MSH - the endogenous ligand for melanocortin receptors. KPV retains anti-inflammatory activity through a mechanism that partially overlaps with the broader melanocortin system, making it a related compound of interest for researchers studying melanocortin biology and inflammation.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eWhen to also consider MOTS-c: \u003c\/span\u003e\u003cspan\u003eFor research programmes combining melanocortin metabolic research with mitochondrial biology, our \u003c\/span\u003e\u003ca href=\"https:\/\/heliopeptides.com\/products\/mots-c-vial\"\u003e\u003cspan\u003eMOTS-c 10MG Vial\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e covers AMPK-mediated metabolic regulation - a complementary pathway to MC3R\/MC4R-mediated energy homeostasis.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 dir=\"ltr\"\u003e\u003cspan\u003eShipping \u0026amp; Fulfilment\u003c\/span\u003e\u003c\/h2\u003e\n\u003cdiv dir=\"ltr\" align=\"left\"\u003e\n\u003ctable\u003e\n\u003ccolgroup\u003e\n\u003ccol width=\"200\"\u003e\n\u003ccol width=\"424\"\u003e\n\u003c\/colgroup\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eDetail\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003ePolicy\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eSame-Day Dispatch\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eOrders placed before the daily cut-off ship same day from our US facility\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eFree Shipping\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eOn all orders over $100\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eDomestic Delivery\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003e1–3 business days within the USA\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eCold-Chain Packaging\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eAll vials ship with cold-chain protection to maintain peptide integrity in transit\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003ePayment Methods\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eCredit\/debit card (3D Secure), bank transfer, ETH, BTC, USDC\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eCustomer Service\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003e1-855-435-4633  ·  info@heliopeptides.com  ·  Live Chat on site\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003cp dir=\"ltr\"\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003ch2 dir=\"ltr\"\u003e\u003cspan\u003eFrequently Asked Questions\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eWhat is PT-141 (Bremelanotide) used for in research?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003ePT-141 is studied in controlled laboratory settings for melanocortin receptor pharmacology (MC1R, MC3R, MC4R, MC5R), central nervous system neuroendocrine signalling, hypothalamic autonomic pathway research, MC1R-mediated pigmentation biology, MC3R\/MC4R energy homeostasis models, and comparative melanocortin agonist studies. Research use only - not for human or animal consumption.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eWhat is the difference between PT-141 and Melanotan II?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003ePT-141 (Bremelanotide) is a cyclic heptapeptide - it was identified as the active des-glycine metabolite of Melanotan II and formed into a cyclic lactam structure. Our \u003c\/span\u003e\u003ca href=\"https:\/\/heliopeptides.com\/products\/melanotan-2-vial\"\u003e\u003cspan\u003eMelanotan II Vial\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e is a linear peptide. The cyclic structure of PT-141 confers different metabolic stability, receptor subtype selectivity, and pharmacokinetic profile compared to the linear Melanotan II parent compound. Comparative studies between the two are a well-established design in melanocortin receptor structure-activity relationship research.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eWhich melanocortin receptors does PT-141 activate?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003ePT-141 is a pan-melanocortin receptor agonist with activity at MC1R (melanocytes, pigmentation), MC3R (hypothalamus, energy homeostasis), MC4R (CNS, autonomic function), and MC5R (exocrine glands). Its primary pharmacological interest in current research is centred on MC4R (CNS autonomic pathways) and MC3R (energy homeostasis and adiposity), with MC1R activity relevant to pigmentation and melanocyte biology research.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eWhat is the molecular weight of PT-141?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003e1,025.17 g\/mol. Molecular formula C₅₀H₆₈N₁₄O₁₀. CAS number 189691-06-3. Cyclic heptapeptide with a lactam bridge between Asp and Lys residues in the cyclic structure.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eHow do I reconstitute PT-141?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eAdd bacteriostatic water or sterile water slowly along the inner vial wall. Gently swirl until dissolved. If full dissolution is not achieved in water, add a small volume of 0.1% acetic acid first, then dilute to target volume in sterile water. Do not shake. Full reconstitution protocol on our \u003c\/span\u003e\u003ca href=\"https:\/\/heliopeptides.com\/faq\"\u003e\u003cspan\u003eFAQ page\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eHow should I store PT-141?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eShort-term: 4°C. Long-term: -80°C. Keep away from direct light. Avoid repeated freeze-thaw cycles. Maintain near-neutral pH in storage solutions. Reconstituted solution: 4°C for 2–4 weeks, or -80°C in aliquots for longer storage.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eIs every batch of PT-141 third-party tested?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eYes - every batch. ISO 17025-accredited laboratory testing confirms identity, cyclic structure by MS, purity (≥99%), and assay content at 10MG. Visit our \u003c\/span\u003e\u003ca href=\"https:\/\/heliopeptides.com\/certificate-of-analysis\"\u003e\u003cspan\u003eCertificate of Analysis page\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e or email info@heliopeptides.com to request your batch COA.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eWhat is the significance of PT-141's cyclic structure in research?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eThe cyclic lactam structure of PT-141 is pharmacologically significant for three reasons: (1) it confers greater metabolic stability than linear Melanotan II, extending plasma half-life in vivo; (2) it alters the receptor subtype selectivity profile relative to the linear parent compound; (3) it affects the three-dimensional presentation of pharmacophore residues to the receptor binding pocket. For structure-activity relationship research, the cyclic vs linear comparison with \u003c\/span\u003e\u003ca href=\"https:\/\/heliopeptides.com\/products\/melanotan-2-vial\"\u003e\u003cspan\u003eMelanotan II\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e is a fundamental experimental design.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eWhere is Helio Peptides PT-141 manufactured?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eSynthesised in the United States by solid-phase peptide synthesis (SPPS) with cyclisation step, in a controlled US-based facility. USA made, USA tested, shipped same day with cold-chain packaging.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eWhat is the relationship between PT-141 and α-MSH?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eα-MSH (alpha-melanocyte-stimulating hormone) is the primary endogenous ligand for melanocortin receptors - a 13-amino acid peptide derived from POMC (proopiomelanocortin). PT-141 is a synthetic cyclic heptapeptide that mimics the pharmacophore of α-MSH at melanocortin receptors. Our \u003c\/span\u003e\u003ca href=\"https:\/\/heliopeptides.com\/products\/kpv-vial\"\u003e\u003cspan\u003eKPV 10MG Vial\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e is the C-terminal tripeptide of α-MSH (Lys-Pro-Val) - a naturally derived melanocortin-related peptide with documented anti-inflammatory activity through MC receptor-associated pathways.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eDoes Helio Peptides ship internationally?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eContact info@heliopeptides.com or call 1-855-435-4633 for current international shipping availability. Domestic US orders: same-day dispatch, 1–3 business day delivery.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eWhat payment methods are accepted?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eCredit\/debit card (3D Secure), bank transfer, Ethereum (ETH), Bitcoin (BTC), and USDC at locked exchange rates.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eIs PT-141 legal to buy in the USA?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003ePT-141 (Bremelanotide) is sold as a research chemical for laboratory use only. It is not a scheduled controlled substance in the United States in its research-grade form. Note that Bremelanotide has been approved by the FDA as a pharmaceutical under the brand name Vyleesi - the Helio Peptides product is a research-grade compound and is not the pharmaceutical product. All purchases must comply with applicable federal and state laws. Buyers confirm research intent at checkout.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eWhat does the Certificate of Analysis include?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eBatch number, testing date, ISO 17025 facility credentials, HPLC chromatogram confirming identity and purity at ≥99%, mass spectrometry data confirming molecular weight at 1,025.17 g\/mol and cyclic structure, and assay result confirming 10MG content. Request via our \u003c\/span\u003e\u003ca href=\"https:\/\/heliopeptides.com\/certificate-of-analysis\"\u003e\u003cspan\u003eCertificate of Analysis page\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e or email info@heliopeptides.com with your order number.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cstrong\u003eIs there a bulk discount on PT-141?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eYes. Pack of 10 at $35.96 per vial - 10% saving over the $39.95 single price, $359.60 total for 100MG. For larger institutional or wholesale quantities, contact \u003c\/span\u003e\u003ca href=\"https:\/\/heliopeptides.com\/wholesale\"\u003e\u003cspan\u003eour wholesale team\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 dir=\"ltr\"\u003e\u003cspan\u003eExplore More From Helio Peptides\u003c\/span\u003e\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003ca href=\"https:\/\/heliopeptides.com\/products\/melanotan-2-vial\"\u003e\u003cspan\u003eMelanotan II (MT-II) Vial\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e - linear parent melanocortin agonist, comparative MCR pharmacology research\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003ca href=\"https:\/\/heliopeptides.com\/products\/kpv-vial\"\u003e\u003cspan\u003eKPV 10MG Vial\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e - C-terminal α-MSH tripeptide, anti-inflammatory and melanocortin-adjacent research\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003ca href=\"https:\/\/heliopeptides.com\/products\/ghk-cu-vial\"\u003e\u003cspan\u003eGHK-Cu 50MG Vial\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e - copper peptide, melanocyte biology and skin matrix remodelling research\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003ca href=\"https:\/\/heliopeptides.com\/products\/bpc-157-vial\"\u003e\u003cspan\u003eBPC-157 Vial\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e - tissue repair, dopaminergic and serotonergic system interactions\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003ca href=\"https:\/\/heliopeptides.com\/products\/thymosin-alpha-1-5mg-vial\"\u003e\u003cspan\u003eThymosin Alpha 1 5MG Vial\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e - immune modulation, neuroimmunology research\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003ca href=\"https:\/\/heliopeptides.com\/products\/mots-c-vial\"\u003e\u003cspan\u003eMOTS-c 10MG Vial\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e - mitochondrial peptide, AMPK metabolic pathway research\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003ca href=\"https:\/\/heliopeptides.com\/products\/aod-9604-vial\"\u003e\u003cspan\u003eAOD-9604 Vial\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e - GH fragment, lipolysis and adipose biology research\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003ca href=\"https:\/\/heliopeptides.com\/products\/slu-pp-332-5mg-vial\"\u003e\u003cspan\u003eSLU-PP-332 5MG Vial\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e - pan-ERR agonist, metabolic syndrome and mitochondrial biogenesis research\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003ca href=\"https:\/\/heliopeptides.com\/certificate-of-analysis\"\u003e\u003cspan\u003eCertificate of Analysis \u0026amp; Testing\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e - full explanation of our ISO 17025 testing methodology\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli dir=\"ltr\" aria-level=\"1\"\u003e\n\u003cp dir=\"ltr\" role=\"presentation\"\u003e\u003ca href=\"https:\/\/heliopeptides.com\/wholesale\"\u003e\u003cspan\u003eWholesale \u0026amp; Bulk Orders\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e - institutional pricing for research programmes requiring consistent supply\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eAll products sold on heliopeptides.com are intended solely for laboratory research and are not for human or animal consumption. These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease. By purchasing, the buyer confirms they are a qualified researcher and agrees to comply with all applicable federal and state laws. Not for sale to persons under the age of 21.\u003c\/span\u003e\u003c\/p\u003e","brand":"heliopeptides","offers":[{"title":"Default Title","offer_id":49030639517939,"sku":null,"price":39.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0825\/8791\/0387\/files\/Helio_Vial_PT-141_10MG_Render.png?v=1778317175","url":"https:\/\/heliopeptides.com\/products\/pt-141-10mg-vial","provider":"Helio Peptides","version":"1.0","type":"link"}