Epithalon - 10MG
About Epithalon - 10MG
Epithalon (also written Epitalon; sequence Ala-Glu-Asp-Gly, abbreviated AEDG) is a synthetic tetrapeptide developed as the short-chain analogue of the pineal polypeptide preparation Epithalamin. First synthesized in the laboratory of Vladimir Khavinson, it has become a widely referenced model compound in gerontological and telomere-biology research. With a molecular formula of C14H22N4O9 and a molecular weight of 390.35 g/mol, Epithalon is one of the smallest peptides studied in the context of cellular senescence and pineal regulation.
Research literature on Epithalon centers on its reported influence over telomerase activity in cultured somatic cells, its interactions with chromatin and specific gene-promoter regions, and its proposed role in circadian and neuroendocrine signaling associated with the pineal gland. These investigations position AEDG as a peptide bioregulator model, though the precise molecular targets and mechanisms remain an active subject of study. This material is supplied strictly for laboratory research use.
Research use only — not for human or animal consumption. Per-batch documentation is provided with the material.
Handling and Storage Tips:
Keep peptides cold and away from light once received.
For short-term use (days to weeks), refrigeration at 4°C (39°F) is acceptable.
Lyophilized peptides are typically stable at room temperature for several weeks, making it suitable for moderate-term storage.
For long-term storage (months to years), it’s best to freeze peptides at -80°C (-112°F). Freezing optimally preserves peptide stability for extended periods.
FDA Disclosure & Intended Use:
FDA Disclosure: The statements on this website and the products sold herein have not been evaluated by the U.S. Food and Drug Administration (FDA). These products are not intended to diagnose, treat, cure, or prevent any disease. Products sold are for Research Use Only and are not for human or animal use.
Intended Purpose: Products sold on this site are intended solely for basic laboratory research, pharmaceutical research, or the development of new tests. They are not intended for diagnostic, therapeutic, or clinical use.
Specifications
- MaterialEpithalon - 10MG
- Also searched asEpitalon
- Research AreaLongevity Research
- Presentation—
- CAS Number307297-39-8
- Molecular FormulaC14H22N4O9
- Molecular Weight390.35 g/mol
- TypeSynthetic tetrapeptide
- Receptor / TargetProposed telomerase / gene-expression and pineal-peptide signaling (target not fully defined)
- PubChem CID219042 →
Ala-Glu-Asp-Gly
- Purity (HPLC)≥99%
- Identity (MS)Confirmed to specification
- TestingAccredited (ISO 17025) third-party laboratory
- DocumentationPer-batch COA →
Published research on Epithalon has reported activation of telomerase and elongation of telomeres in cultured human fibroblast and somatic cell populations, alongside observations of altered gene-promoter binding and modulation of melatonin-associated rhythms in animal models. The peptide is frequently framed within the concept of "peptide bioregulation," in which short peptides are proposed to influence tissue-specific gene expression.
These reports are drawn largely from in vitro systems and rodent studies; mechanisms remain incompletely characterized and results are not established for humans. Epithalon is offered solely as a research reagent.
Epithalon was designed as the tetrapeptide analogue of Epithalamin, a peptide extract of the pineal gland studied in the Soviet Union and Russia beginning in the 1980s. Its synthesis and much of the foundational research are attributed to Russian gerontologist Vladimir Khavinson and colleagues at the St. Petersburg Institute of Bioregulation and Gerontology, who advanced the broader "peptide bioregulator" framework.
- Khavinson VK, et al. Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bull Exp Biol Med. 2003;135(6):590-592.
- Khavinson VKh, Bondarev IE, Butyugov AA. Epithalon peptide increases the lifespan of Drosophila melanogaster. Bull Exp Biol Med. 2000;130(12):1105-1107.
- Anisimov VN, et al. Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in mice. Biogerontology. 2003;4(4):193-202.
- PubChem Compound Summary for CID 219042, Epitalon. National Center for Biotechnology Information.
View compound profile on NIH PubChem →
Cited literature refers to laboratory and preclinical research. This material is supplied strictly for research use only and is not intended to diagnose, treat, cure, or prevent any disease.
Are these research materials third-party tested?
Yes — every batch is analysed by an accredited (ISO 17025) independent laboratory using HPLC and mass spectrometry, with a per-batch Certificate of Analysis.
What purity are the materials?
Materials are verified to 99%+ HPLC purity. Any batch that does not meet the threshold is not released.
Do you provide a Certificate of Analysis (COA)?
Yes. Per-batch COA documentation is provided and is traceable by lot number.
Where do you ship from?
Materials are shipped from the USA in discreet, protective packaging.
Are these products for human use?
No. All materials are sold strictly for laboratory research use only — not for human or animal consumption, diagnosis, treatment, or prevention of any disease.
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