Skin & Cosmetic Research

GHK - Cu - 50MG

CAS # 89030-95-5

A naturally occurring copper tripeptide that promotes tissue remodeling, wound healing, and collagen synthesis in animal and in vitro studies. Premium Research Peptide.

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Purity≥99% HPLC
FormResearch material
CAS89030-95-5
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About GHK - Cu - 50MG

GHK-Cu, also designated Copper Tripeptide-1, is a copper(II)-chelated complex of the naturally occurring tripeptide glycyl-L-histidyl-L-lysine (Gly-His-Lys, GHK). The GHK sequence was first isolated from human plasma, and its high affinity for divalent copper ions gives rise to the blue-tinted 1:1 complex catalogued in PubChem under CID 71587328. In research settings the compound is studied as a model system for copper transport, extracellular-matrix biology, and copper-dependent enzymatic activity.

Supplied as a lyophilized powder in a 50mg vial, Helio's GHK-Cu is intended strictly for in vitro and preclinical laboratory investigation. Reported literature explores its interaction with fibroblast cultures, collagen and glycosaminoglycan expression, and copper-signaling pathways. All material is offered for Research Use Only and is not for human or veterinary use.

Research use only — not for human or animal consumption. Per-batch documentation is provided with the material.

Handling and Storage Tips:

Keep peptides cold and away from light once received.

For short-term use (days to weeks), refrigeration at 4°C (39°F) is acceptable.

Lyophilized peptides are typically stable at room temperature for several weeks, making it suitable for moderate-term storage.

For long-term storage (months to years), it’s best to freeze peptides at -80°C (-112°F). Freezing optimally preserves peptide stability for extended periods.

FDA Disclosure & Intended Use:

FDA Disclosure: The statements on this website and the products sold herein have not been evaluated by the U.S. Food and Drug Administration (FDA). These products are not intended to diagnose, treat, cure, or prevent any disease. Products sold are for Research Use Only and are not for human or animal use.

Intended Purpose: Products sold on this site are intended solely for basic laboratory research, pharmaceutical research, or the development of new tests. They are not intended for diagnostic, therapeutic, or clinical use.

Specifications

Identification
  • MaterialGHK - Cu - 50MG
  • Also searched asGHK Cu, GHKcu, Copper Peptide, GHK Copper
  • Research AreaSkin & Cosmetic Research
  • Presentation
  • CAS Number89030-95-5
  • Molecular FormulaC14H24CuN6O4
  • Molecular Weight403.92 g/mol
  • TypeCopper-bound tripeptide complex
  • Receptor / TargetCopper-dependent enzymes; matrix and gene-expression modulation (in vitro)
  • PubChem CID71587328 →
Amino Acid Sequence

Gly-His-Lys (copper(II) complex)

Analytical Data
  • Purity (HPLC)≥99%
  • Identity (MS)Confirmed to specification
  • TestingAccredited (ISO 17025) third-party laboratory
  • DocumentationPer-batch COA →
Key Characteristics
Molecular FormulaC14H24CuN6O4
Molecular Weight403.92 g/mol
CAS Number89030-95-5
PubChem CID71587328
StructureCopper(II) complex of Gly-His-Lys tripeptide
Receptor / TargetCopper-dependent enzymes; ECM and gene-expression modulation (in vitro)
FormLyophilized powder
SolubilitySoluble in water
StorageLyophilized: stable at room temperature short-term; -20°C to -80°C for long-term storage; protect from light
StabilityRefrigerate at 4°C for short-term use; freeze at -80°C for extended storage
Research Context
Extracellular-matrix biologyInvestigated in fibroblast cultures for effects on collagen, elastin, and glycosaminoglycan synthesis.
Copper transport and homeostasisStudied as a small-molecule copper-delivery and chelation model in cell systems.
Gene-expression modulationExplored in transcriptomic studies reporting broad up- and down-regulation patterns in cultured cells.
Wound-healing modelsUsed in preclinical tissue-repair and angiogenesis research paradigms.
Antioxidant enzyme researchExamined in relation to copper-dependent superoxide dismutase and related enzyme activity.
Research Findings

Published in vitro work reports that GHK and its copper complex can influence fibroblast behavior and the expression of extracellular-matrix components such as collagen and glycosaminoglycans. Broad gene-expression profiling studies have described GHK-Cu as modulating large numbers of genes in cultured cells, prompting continued interest as a research tool for tissue-remodeling pathways.

The copper-binding property is central to much of the reported activity, and researchers frequently study GHK-Cu as a defined-stoichiometry model for delivering copper into cellular systems. Findings are preclinical and experimental; no human efficacy conclusions are drawn.

History

The GHK tripeptide was first identified in the 1970s by Loren Pickart as a factor in human plasma, and its strong affinity for copper(II) led to characterization of the GHK-Cu complex. It has since become a widely referenced subject in matrix-biology and copper-signaling research.

References
  1. Pickart L, Margolina A. Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. Int J Mol Sci. 2018;19(7):1987.
  2. Pickart L. The human tri-peptide GHK and tissue remodeling. J Biomater Sci Polym Ed. 2008;19(8):969-988.
  3. PubChem Compound Summary for CID 71587328, Copper Peptide GHK-Cu. National Library of Medicine.

View compound profile on NIH PubChem →

Cited literature refers to laboratory and preclinical research. This material is supplied strictly for research use only and is not intended to diagnose, treat, cure, or prevent any disease.

Why researchers choose Helio Peptides
99%+ PurityHPLC-verified every batch
Accredited TestingIndependent ISO 17025 laboratory
Per-Batch COADocumentation tied to your lot
Made in the USADiscreet, protected shipping
Frequently Asked
Are these research materials third-party tested?

Yes — every batch is analysed by an accredited (ISO 17025) independent laboratory using HPLC and mass spectrometry, with a per-batch Certificate of Analysis.

What purity are the materials?

Materials are verified to 99%+ HPLC purity. Any batch that does not meet the threshold is not released.

Do you provide a Certificate of Analysis (COA)?

Yes. Per-batch COA documentation is provided and is traceable by lot number.

Where do you ship from?

Materials are shipped from the USA in discreet, protective packaging.

Are these products for human use?

No. All materials are sold strictly for laboratory research use only — not for human or animal consumption, diagnosis, treatment, or prevention of any disease.

RESEARCH USE ONLY · NOT FOR HUMAN OR VETERINARY USE · 21+