Melanotan I – 10MG
About Melanotan I – 10MG
Melanotan I, also known as afamelanotide, is a synthetic linear analog of alpha-melanocyte-stimulating hormone (alpha-MSH). It is a tridecapeptide (13 residues) built on the [Nle4, D-Phe7]-alpha-MSH modification, first synthesized in the search for a more potent and stable melanocortin agonist. It is catalogued under CAS 75921-69-6 and PubChem CID 16197727, and functions as a non-selective melanocortin-receptor agonist with particular activity at MC1R, the receptor governing melanin synthesis.
Supplied as a 10mg lyophilized vial, Helio's Melanotan I is intended strictly for in vitro and preclinical Research Use Only and is not for human or veterinary use. Research applications center on melanocortin-receptor pharmacology and pigmentation-pathway biology.
Research use only — not for human or animal consumption. Per-batch documentation is provided with the material.
Handling and Storage Tips:
Keep peptides cold and away from light once received.
For short-term use (days to weeks), refrigeration at 4°C (39°F) is acceptable.
Lyophilized peptides are typically stable at room temperature for several weeks, making it suitable for moderate-term storage.
For long-term storage (months to years), it’s best to freeze peptides at -80°C (-112°F). Freezing optimally preserves peptide stability for extended periods.
FDA Disclosure & Intended Use:
FDA Disclosure: The statements on this website and the products sold herein have not been evaluated by the U.S. Food and Drug Administration (FDA). These products are not intended to diagnose, treat, cure, or prevent any disease. Products sold are for Research Use Only and are not for human or animal use.
Intended Purpose: Products sold on this site are intended solely for basic laboratory research, pharmaceutical research, or the development of new tests. They are not intended for diagnostic, therapeutic, or clinical use.
Specifications
- MaterialMelanotan I – 10MG
- Also searched asMelanotan 1, MT1, MT-1
- Research AreaSkin & Cosmetic Research
- Presentation—
- CAS Number75921-69-6
- Molecular FormulaC78H111N21O19
- Molecular Weight1646.85 g/mol
- TypeLinear acetylated, C-amidated tridecapeptide (alpha-MSH analog)
- Receptor / TargetMelanocortin receptors (non-selective; MC1R agonist)
- PubChem CID16197727 →
Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2
- Purity (HPLC)≥99%
- Identity (MS)Confirmed to specification
- TestingAccredited (ISO 17025) third-party laboratory
- DocumentationPer-batch COA →
Melanotan I (afamelanotide) arose from work identifying [Nle4, D-Phe7]-alpha-MSH as an analog roughly a thousand-fold more potent than native alpha-MSH, owing to substitutions that improve receptor affinity and metabolic stability. It shares the conserved His-Phe-Arg-Trp melanocortin active-site motif and acts primarily through MC1R to drive melanin synthesis in preclinical melanocyte models.
The compound is well characterized in the melanocortin literature and has an established regulatory history as a clinical agent for erythropoietic protoporphyria; however, material offered here is for laboratory research only, with no human efficacy or dosing claims made.
Melanotan was developed in the 1980s by Victor Hruby and colleagues at the University of Arizona, who identified [Nle4, D-Phe7]-alpha-MSH as a highly potent, stable melanocortin agonist later designated Melanotan I and subsequently developed as afamelanotide.
- PubChem Compound Summary for CID 16197727, Afamelanotide. National Library of Medicine.
- Sawyer TK, et al. 4-Norleucine, 7-D-phenylalanine-alpha-melanocyte-stimulating hormone: a highly potent alpha-melanotropin. Proc Natl Acad Sci USA. 1980;77(10):5754-5758.
- Lengweiler S, et al. Afamelanotide in erythropoietic protoporphyria. N Engl J Med. 2015;373:48-59.
View compound profile on NIH PubChem →
Cited literature refers to laboratory and preclinical research. This material is supplied strictly for research use only and is not intended to diagnose, treat, cure, or prevent any disease.
Are these research materials third-party tested?
Yes — every batch is analysed by an accredited (ISO 17025) independent laboratory using HPLC and mass spectrometry, with a per-batch Certificate of Analysis.
What purity are the materials?
Materials are verified to 99%+ HPLC purity. Any batch that does not meet the threshold is not released.
Do you provide a Certificate of Analysis (COA)?
Yes. Per-batch COA documentation is provided and is traceable by lot number.
Where do you ship from?
Materials are shipped from the USA in discreet, protective packaging.
Are these products for human use?
No. All materials are sold strictly for laboratory research use only — not for human or animal consumption, diagnosis, treatment, or prevention of any disease.
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