TB-500 Dissolvable Strips
About TB-500 Dissolvable Strips
TB-500 is the research designation associated with Thymosin Beta-4 (Tβ4), a naturally occurring 43-amino-acid peptide and the principal G-actin-sequestering molecule in mammalian cells. As commonly supplied, the full-length peptide carries an N-terminal acetyl group and the sequence Ac-SDKPDMAEIEKFDKSKLKKTETQEKNPLPSKETIEQEKQAGES, corresponding to molecular formula C212H350N56O78S, molecular weight approximately 4963 g/mol, CAS 77591-33-4 and PubChem CID 16132341. Note that some literature applies the "TB-500" name to a shorter active fragment; Helio material corresponds to the full-length Thymosin Beta-4 sequence.
Thymosin Beta-4 has been studied for roles in actin regulation, cell migration, angiogenesis and tissue repair. Its seven-residue actin-binding motif has been identified as essential for angiogenic activity. Helio supplies TB-500 as a lyophilized powder in 5 mg vials. This material is offered for Research Use Only and is not intended for human or veterinary use.
Format: supplied as dissolvable oral strips (30 per box) — a fast, needle-free research format. Exact per-strip potency is printed on the packaging.
Research use only — not for human or animal consumption. Per-batch documentation is provided with the material.
TB-500 is a synthetic version of the active region of Thymosin Beta-4, studied in recovery, tissue-repair, and flexibility research.
Supplied as dissolvable oral strips — 30 strips per box — for fast, consistent, needle-free handling in the research setting. Exact per-strip potency is printed on the packaging.
Every batch is independently tested by an ISO 17025-accredited laboratory to ≥99% purity, with a certificate of analysis on file for its exact lot.
For research use only. Not for human or veterinary consumption, diagnosis, or treatment.
Specifications
- MaterialTB-500 Dissolvable Strips
- Also searched asTB500, TB 500, Thymosin Beta-4, TB-4
- Research AreaRecovery Research
- PresentationDissolvable Strips
- CAS Number77591-33-4
- Molecular FormulaC212H350N56O78S
- Molecular Weight4963.44 g/mol
- TypeSynthetic 43-residue peptide (full-length Thymosin Beta-4)
- Receptor / TargetNo classical membrane receptor; primary molecular target is monomeric G-actin (actin-sequestering), with pro-angiogenic activity localized to the actin-binding motif
- PubChem CID16132341 →
Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser-OH (N-acetylated, 43 aa)
- Purity (HPLC)≥99%
- Identity (MS)Confirmed to specification
- TestingAccredited (ISO 17025) third-party laboratory
- DocumentationPer-batch COA →
Thymosin Beta-4 is characterized in the literature primarily as an actin-sequestering peptide that "moonlights" as a tissue-repair factor. Studies including Malinda et al. (1999) reported accelerated reepithelialization, angiogenesis and collagen deposition in rodent dermal wound models, while Grant and colleagues demonstrated that the actin-binding site is required for angiogenic activity.
These findings derive from animal and in-vitro experiments and describe an endogenous peptide's biology; controlled human efficacy for the research compound has not been established. Data should be treated as experimental.
Thymosin Beta-4 was originally isolated from thymus tissue and later recognized as the major intracellular actin-sequestering peptide; it has been studied since the 1980s-1990s for actin regulation and wound healing. In the research-peptide market the "TB-500" name became attached to this sequence (and to a related active fragment). It remains an unapproved investigational compound for laboratory research only.
- Malinda KM, Sidhu GS, Mani H, et al. Thymosin beta4 accelerates wound healing. Journal of Investigative Dermatology. 1999;113(3):364-368.
- Philp D, Kleinman HK. Animal studies with thymosin beta4, a multifunctional tissue repair and regeneration peptide. Annals of the New York Academy of Sciences. 2010;1194:81-86.
- Goldstein AL, Hannappel E, Kleinman HK. Thymosin beta4: actin-sequestering protein moonlights to repair injured tissues. Trends in Molecular Medicine. 2005;11(9):421-429.
- Bock-Marquette I, Saxena A, White MD, et al. Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair. Nature. 2004;432(7016):466-472.
View compound profile on NIH PubChem →
Cited literature refers to laboratory and preclinical research. This material is supplied strictly for research use only and is not intended to diagnose, treat, cure, or prevent any disease.
Are these research materials third-party tested?
Yes — every batch is analysed by an accredited (ISO 17025) independent laboratory using HPLC and mass spectrometry, with a per-batch Certificate of Analysis.
What purity are the materials?
Materials are verified to 99%+ HPLC purity. Any batch that does not meet the threshold is not released.
Do you provide a Certificate of Analysis (COA)?
Yes. Per-batch COA documentation is provided and is traceable by lot number.
Where do you ship from?
Materials are shipped from the USA in discreet, protective packaging.
Are these products for human use?
No. All materials are sold strictly for laboratory research use only — not for human or animal consumption, diagnosis, treatment, or prevention of any disease.
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