MOTS-c 10MG Research Vial - Mitochondrial-Derived Peptide | Third-Party Tested
About MOTS-c 10MG Research Vial - Mitochondrial-Derived Peptide | Third-Party Tested
MOTS-c (Mitochondrial Open reading frame of the Twelve S rRNA type-c) is a 16-amino-acid mitochondrial-derived peptide (MDP) encoded within the MT-RNR1 / 12S ribosomal RNA gene of the human mitochondrial genome. Its sequence is MRWQEMGYIFYPRKLR, with CAS 1627580-64-6, molecular formula C101H163N33O24, and a molecular weight of approximately 2174.62 g/mol. As one of a small class of peptides encoded by the mitochondrial rather than the nuclear genome, MOTS-c is studied as a signaling molecule capable of coordinating systemic metabolic responses independent of nuclear gene expression.
MOTS-c was discovered in 2015 and has since become a central molecule in mitochondrial and metabolic biology research. Published studies characterize it as an activator of the AMPK pathway that translocates to the nucleus under metabolic stress to regulate adaptive gene expression. It is offered here solely as MOTS-c research peptide material for laboratory investigation.
Research use only — not for human or animal consumption. Per-batch documentation is provided with the material.
MOTS-c 10MG Research Vial – Mitochondrial-Derived Peptide | Third-Party Tested
MOTS-c is a mitochondrial-derived research peptide consisting of a defined 16-amino-acid sequence. It is referenced in laboratory literature examining mitochondrial signaling, cellular energy pathways, metabolic signaling, and related biochemical mechanisms.
Each Helio Peptides MOTS-c research vial contains 10MG of lyophilized research material.
Product Specifications
Compound: MOTS-c
Research Format: Lyophilized powder
Content: 10MG per vial
Batch produced and batch tested
Third-party analytical testing
Identity and purity verification
Certificate of Analysis available
Manufactured in the USA
Intended exclusively for laboratory research
Research Use Only
This product is intended solely for laboratory research purposes. Not for human or animal consumption. Not intended to diagnose, treat, cure, or prevent any disease.
Specifications
- MaterialMOTS-c 10MG Research Vial - Mitochondrial-Derived Peptide | Third-Party Tested
- Also searched asMOTS c, MOTSc
- Research AreaMetabolic Research
- Presentation—
- CAS Number1627580-64-6
- Molecular FormulaC101H163N33O24
- Molecular Weight2174.62 g/mol
- TypeMitochondrial-derived peptide (MDP)
- Receptor / TargetAMPK signaling pathway (folate–AICAR–AMPK axis)
MRWQEMGYIFYPRKLR
- Purity (HPLC)≥99%
- Identity (MS)Confirmed to specification
- TestingAccredited (ISO 17025) third-party laboratory
- DocumentationPer-batch COA →
MOTS-c has been investigated in experimental and in-vitro settings as a regulator of cellular energy metabolism. Published research reports that it activates the AMPK pathway and influences the folate–AICAR–AMPK axis, with preclinical studies in rodent and cell models examining insulin sensitivity, glucose uptake, and fatty acid oxidation under metabolic stress.
Additional work has characterized MOTS-c as an exercise-induced peptide that translocates to the nucleus to regulate stress-adaptive gene expression, and it has been studied in the context of aging metabolic homeostasis and physical capacity. All described observations derive from preclinical, experimental, or in-vitro models and are presented for research context only.
MOTS-c was identified in 2015 by Changhan David Lee, Pinchas Cohen, and colleagues at the University of Southern California, who described it as a mitochondrial-derived peptide encoded within the 12S rRNA region of the mitochondrial genome that regulates insulin sensitivity and metabolic homeostasis. Subsequent studies expanded its characterization as an AMPK-activating, exercise-associated regulator, establishing it as a widely studied model peptide in mitochondrial biology.
- Lee C, et al. (2015). The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metabolism.
- Reynolds JC, et al. (2021). MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nature Communications.
- Kim KH, et al. (2018). The mitochondrial-derived peptide MOTS-c is a regulator of plasma metabolites and enhances insulin sensitivity. Biochemical and Biophysical Research Communications.
Cited literature refers to laboratory and preclinical research. This material is supplied strictly for research use only and is not intended to diagnose, treat, cure, or prevent any disease.
Are these research materials third-party tested?
Yes — every batch is analysed by an accredited (ISO 17025) independent laboratory using HPLC and mass spectrometry, with a per-batch Certificate of Analysis.
What purity are the materials?
Materials are verified to 99%+ HPLC purity. Any batch that does not meet the threshold is not released.
Do you provide a Certificate of Analysis (COA)?
Yes. Per-batch COA documentation is provided and is traceable by lot number.
Where do you ship from?
Materials are shipped from the USA in discreet, protective packaging.
Are these products for human use?
No. All materials are sold strictly for laboratory research use only — not for human or animal consumption, diagnosis, treatment, or prevention of any disease.
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