5-Amino - 1mq - Capsules - 60CT
About 5-Amino - 1mq - Capsules - 60CT
5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), not a peptide. Structurally it is a quinolinium scaffold bearing a primary amine at the 5-position and a permanent positive charge introduced by N1-methylation; it is most commonly supplied and studied as the iodide salt (CAS 42464-96-0, C10H11IN2, 286.11 g/mol), while the active cation corresponds to C10H11N2+ (PubChem CID 950107). NNMT catalyzes the S-adenosyl-L-methionine (SAM)-dependent methylation of nicotinamide to 1-methylnicotinamide, a reaction positioned at the intersection of methyl-donor balance and NAD+ salvage. 5-Amino-1MQ occupies the enzyme active site and slows this methylation step in experimental systems.
The compound emerged from medicinal-chemistry programs seeking selective, cell-permeable NNMT inhibitors as tools for adipose and skeletal-muscle metabolism research. In preclinical and in-vitro reports, 5-Amino-1MQ research material has been used to interrogate how NNMT activity influences cellular NAD+ pools, adipocyte lipogenesis, energy expenditure, and myoblast differentiation. It is offered here strictly as 5-Amino-1MQ research material for laboratory investigation.
Research use only — not for human or animal consumption. Per-batch documentation is provided with the material.
Handling and Storage Tips:
Keep peptides cold and away from light once received.
For short-term use (days to weeks), refrigeration at 4°C (39°F) is acceptable.
Lyophilized peptides are typically stable at room temperature for several weeks, making it suitable for moderate-term storage.
For long-term storage (months to years), it’s best to freeze peptides at -80°C (-112°F). Freezing optimally preserves peptide stability for extended periods.
FDA Disclosure & Intended Use:
FDA Disclosure: The statements on this website and the products sold herein have not been evaluated by the U.S. Food and Drug Administration (FDA). These products are not intended to diagnose, treat, cure, or prevent any disease. Products sold are for Research Use Only and are not for human or animal use.
Intended Purpose: Products sold on this site are intended solely for basic laboratory research, pharmaceutical research, or the development of new tests. They are not intended for diagnostic, therapeutic, or clinical use.
Specifications
- Material5-Amino - 1mq - Capsules - 60CT
- Also searched as5 Amino 1MQ, 5amino1mq
- Research AreaMetabolic Research
- Presentation—
- CAS Number42464-96-0
- Molecular FormulaC10H11IN2
- Molecular Weight286.11 g/mol
- TypeSmall-molecule quinolinium (NNMT inhibitor)
- Receptor / TargetNicotinamide N-methyltransferase (NNMT)
- PubChem CID950107 →
- Purity (HPLC)≥99%
- Identity (MS)Confirmed to specification
- TestingAccredited (ISO 17025) third-party laboratory
- DocumentationPer-batch COA →
5-Amino-1MQ has been investigated in experimental and in-vitro settings as a selective NNMT inhibitor. Published studies report that inhibiting NNMT with quinolinium-class compounds can shift cellular methyl-donor and NAD+ handling, and preclinical work has examined effects on adipocyte size, lipogenic signaling, and whole-body energy expenditure in rodent models of diet-induced obesity.
Additional research has explored NNMT inhibition in skeletal-muscle contexts, including reports that 5-Amino-1MQ promotes myoblast differentiation in cultured cells and influences the regenerative capacity of aged muscle stem cells. All such findings are drawn from preclinical, experimental, or in-vitro models and are presented for research context only.
5-Amino-1MQ arose from academic and industry medicinal-chemistry efforts to develop cell-permeable small-molecule NNMT inhibitors, with quinoline-derived scaffolds described in patent literature and peer-reviewed studies from the mid-2010s onward. Interest in NNMT as a metabolic target grew after the enzyme was linked to adipose-tissue energy metabolism, positioning 5-Amino-1MQ as a widely used tool compound in metabolic and NAD+ research.
- Kraus D, et al. (2014). Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. Nature.
- Neelakantan H, et al. (2017). Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice. Biochemical Pharmacology.
- Neelakantan H, et al. (2019). Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle. Biochemical Pharmacology.
View compound profile on NIH PubChem →
Cited literature refers to laboratory and preclinical research. This material is supplied strictly for research use only and is not intended to diagnose, treat, cure, or prevent any disease.
Are these research materials third-party tested?
Yes — every batch is analysed by an accredited (ISO 17025) independent laboratory using HPLC and mass spectrometry, with a per-batch Certificate of Analysis.
What purity are the materials?
Materials are verified to 99%+ HPLC purity. Any batch that does not meet the threshold is not released.
Do you provide a Certificate of Analysis (COA)?
Yes. Per-batch COA documentation is provided and is traceable by lot number.
Where do you ship from?
Materials are shipped from the USA in discreet, protective packaging.
Are these products for human use?
No. All materials are sold strictly for laboratory research use only — not for human or animal consumption, diagnosis, treatment, or prevention of any disease.
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RESEARCH USE ONLY · NOT FOR HUMAN OR VETERINARY USE · 21+
