Semax Liquid Spray
About Semax Liquid Spray
Semax is a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) derived from the 4-7 fragment of adrenocorticotropic hormone (ACTH), extended at the C-terminus with a Pro-Gly-Pro sequence to confer resistance to enzymatic degradation. Originally developed at the Institute of Molecular Genetics of the Russian Academy of Sciences, it belongs to the class of regulatory ACTH-derived neuropeptides that are devoid of the corticotropic (hormonal) activity of the parent molecule while retaining central-nervous-system effects. Semax is catalogued in PubChem under CID 9811102 and CAS 80714-61-0.
In the experimental literature, Semax has been investigated primarily as a nootropic and neuroprotective agent. Reported mechanisms in rodent models center on up-regulation of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) with concurrent activation of TrkB/TrkA signaling in the hippocampus. Additional studies describe modulation of dopaminergic and serotonergic systems and effects in models of cerebral ischemia. This material is offered strictly for in-vitro and laboratory research and is not intended for human or animal use.
Research use only — not for human or animal consumption. Per-batch documentation is provided with the material.
Handling and Storage Tips:
Keep peptides cold and away from light once received.
For short-term use (days to weeks), refrigeration at 4°C (39°F) is acceptable.
Lyophilized peptides are typically stable at room temperature for several weeks, making it suitable for moderate-term storage.
For long-term storage (months to years), it’s best to freeze peptides at -80°C (-112°F). Freezing optimally preserves peptide stability for extended periods.
FDA Disclosure & Intended Use:
FDA Disclosure: The statements on this website and the products sold herein have not been evaluated by the U.S. Food and Drug Administration (FDA). These products are not intended to diagnose, treat, cure, or prevent any disease. Products sold are for Research Use Only and are not for human or animal use.
Intended Purpose: Products sold on this site are intended solely for basic laboratory research, pharmaceutical research, or the development of new tests. They are not intended for diagnostic, therapeutic, or clinical use.
Specifications
- MaterialSemax Liquid Spray
- Research AreaCognitive Research
- Presentation—
- CAS Number80714-61-0
- Molecular FormulaC37H51N9O10S
- Molecular Weight813.9 g/mol
- TypeSynthetic heptapeptide
- Receptor / TargetMelanocortin / BDNF-TrkB neurotrophin signaling (proposed)
- PubChem CID9811102 →
Met-Glu-His-Phe-Pro-Gly-Pro
- Purity (HPLC)≥99%
- Identity (MS)Confirmed to specification
- TestingAccredited (ISO 17025) third-party laboratory
- DocumentationPer-batch COA →
Published rodent research reports that a single administration of Semax increased hippocampal BDNF protein and exon-III BDNF mRNA levels alongside elevated TrkB tyrosine phosphorylation, identifying the neurotrophin pathway as its most consistently described molecular correlate. Further studies describe activation of central dopaminergic and serotonergic systems and neuroprotective effects in cerebral-ischemia models.
These observations derive from in-vitro systems and animal models and characterize the compound's biochemical behavior in research settings. They do not constitute evidence of clinical efficacy or safety in humans.
Semax was developed in the 1980s-1990s at the Institute of Molecular Genetics of the Russian Academy of Sciences as a metabolically stabilized analog of the ACTH(4-10) fragment, engineered to retain neurotropic activity while eliminating the hormonal actions of full-length ACTH. It has since become a widely referenced tool compound in the neuropeptide literature.
- Dolotov OV, et al. Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus. Brain Research. 2006;1117(1):54-60.
- Eremin KO, et al. Semax, an ACTH(4-10) analogue with nootropic properties, activates dopaminergic and serotoninergic brain systems in rodents. Neurochemical Research. 2005;30(12):1493-1500.
- Tsai SJ. Semax, an analogue of adrenocorticotropin (4-10), is a potential agent for the treatment of attention-deficit hyperactivity disorder and Rett syndrome. Medical Hypotheses. 2007;68(5):1144-1146.
- PubChem Compound Summary for CID 9811102, Semax. National Center for Biotechnology Information.
View compound profile on NIH PubChem →
Cited literature refers to laboratory and preclinical research. This material is supplied strictly for research use only and is not intended to diagnose, treat, cure, or prevent any disease.
Are these research materials third-party tested?
Yes — every batch is analysed by an accredited (ISO 17025) independent laboratory using HPLC and mass spectrometry, with a per-batch Certificate of Analysis.
What purity are the materials?
Materials are verified to 99%+ HPLC purity. Any batch that does not meet the threshold is not released.
Do you provide a Certificate of Analysis (COA)?
Yes. Per-batch COA documentation is provided and is traceable by lot number.
Where do you ship from?
Materials are shipped from the USA in discreet, protective packaging.
Are these products for human use?
No. All materials are sold strictly for laboratory research use only — not for human or animal consumption, diagnosis, treatment, or prevention of any disease.
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