Mk-677 - Capsules - 60CT
About Mk-677 - Capsules - 60CT
MK-677 (Ibutamoren) is a non-peptide, orally active small molecule that acts as a potent agonist of the growth hormone secretagogue receptor (GHS-R1a), the receptor for endogenous ghrelin. Unlike the peptide secretagogues in the GHRP family, MK-677 is a spiropiperidine-based synthetic compound designed for oral bioavailability and metabolic stability, mimicking the GH-stimulating action of ghrelin while resisting the enzymatic degradation that limits peptide agonists.
In research model systems, MK-677 stimulates pulsatile GH release and produces sustained elevations of GH and IGF-1 without markedly affecting cortisol, and it is characterized by a long functional half-life supporting once-daily oral administration in study protocols. It is supplied here as oral capsules containing ibutamoren for laboratory research only, and is not a peptide.
Research use only — not for human or animal consumption. Per-batch documentation is provided with the material.
Handling and Storage Tips:
Keep peptides cold and away from light once received.
For short-term use (days to weeks), refrigeration at 4°C (39°F) is acceptable.
Lyophilized peptides are typically stable at room temperature for several weeks, making it suitable for moderate-term storage.
For long-term storage (months to years), it’s best to freeze peptides at -80°C (-112°F). Freezing optimally preserves peptide stability for extended periods.
FDA Disclosure & Intended Use:
FDA Disclosure: The statements on this website and the products sold herein have not been evaluated by the U.S. Food and Drug Administration (FDA). These products are not intended to diagnose, treat, cure, or prevent any disease. Products sold are for Research Use Only and are not for human or animal use.
Intended Purpose: Products sold on this site are intended solely for basic laboratory research, pharmaceutical research, or the development of new tests. They are not intended for diagnostic, therapeutic, or clinical use.
Specifications
- MaterialMk-677 - Capsules - 60CT
- Also searched asMK677, MK 677, Ibutamoren
- Research AreaGrowth Hormone Research
- Presentation—
- CAS Number159634-47-6
- Molecular FormulaC27H36N4O5S
- Molecular Weight528.7 g/mol
- TypeNon-peptide small molecule (spiropiperidine growth hormone secretagogue)
- Receptor / TargetGrowth hormone secretagogue receptor (GHS-R1a / ghrelin receptor)
- PubChem CID178024 →
- Purity (HPLC)≥99%
- Identity (MS)Confirmed to specification
- TestingAccredited (ISO 17025) third-party laboratory
- DocumentationPer-batch COA →
Research on MK-677 has established it as a potent, orally active ghrelin-receptor agonist that produces dose-dependent, sustained increases in circulating GH and IGF-1 in model systems and clinical study populations, generally without meaningful elevation of cortisol. Its non-peptide structure confers oral bioavailability and a long duration of action relative to peptide secretagogues.
Longer-term studies have examined its effects on the GH/IGF-1 axis and on metabolic and body-composition endpoints; reported observations in study populations include increases in IGF-1 and fluid retention, underscoring its utility as a well-characterized oral secretagogue tool compound.
MK-677 (ibutamoren, originally L-163,191) was developed by Merck in the 1990s as an orally active, non-peptide growth hormone secretagogue derived from earlier GHS peptide pharmacophores. Extensively studied in clinical research on the GH/IGF-1 axis, it never received marketing approval and remains a widely used reference compound in secretagogue research.
- Patchett AA, et al. Design and biological activities of L-163,191 (MK-0677): a potent, orally active growth hormone secretagogue. Proc Natl Acad Sci USA. 1995;92(15):7001-7005.
- Chapman IM, et al. Stimulation of the growth hormone (GH)-insulin-like growth factor I axis by daily oral administration of a GH secretagogue (MK-677) in healthy elderly subjects. J Clin Endocrinol Metab. 1996;81(12):4249-4257.
- Nass R, et al. Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial. Ann Intern Med. 2008;149(9):601-611.
View compound profile on NIH PubChem →
Cited literature refers to laboratory and preclinical research. This material is supplied strictly for research use only and is not intended to diagnose, treat, cure, or prevent any disease.
Are these research materials third-party tested?
Yes — every batch is analysed by an accredited (ISO 17025) independent laboratory using HPLC and mass spectrometry, with a per-batch Certificate of Analysis.
What purity are the materials?
Materials are verified to 99%+ HPLC purity. Any batch that does not meet the threshold is not released.
Do you provide a Certificate of Analysis (COA)?
Yes. Per-batch COA documentation is provided and is traceable by lot number.
Where do you ship from?
Materials are shipped from the USA in discreet, protective packaging.
Are these products for human use?
No. All materials are sold strictly for laboratory research use only — not for human or animal consumption, diagnosis, treatment, or prevention of any disease.
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